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4 predicts incident AD in Japanese-American men: The Honolulu–Asia Aging Study
From the Epidemiology, Demography and Biometry Program (Drs. Havlik, Izmirlian, Brock, and Launer, and D. Foley) National Institute on Aging, National Institutes of Health, Bethesda, MD; the Honolulu-Asia Aging Study (Drs. Petrovitch, Masaki, Curb, and White), Kuakini Medical Center, Honolulu, HI; the Department of Veterans’ Affairs (Dr. Ross), Honolulu, HI; the Department of Medicine (Drs. Petrovitch, Ross, Masaki, Curb, and White) University of Hawaii, John A. Burns School of Medicine, Honolulu, HI; and the Joseph and Kathleen Bryan Alzheimer’s Disease Research Center, Department of Medicine (Neurology) (Dr. Saunders), Duke University Medical Center, Durham, NC.
Address correspondence and reprint requests to Dr. Richard Havlik, Epidemiology, Demography and Biometry Program, National Institute on Aging, Gateway Building Suite 3C-309, Bethesda, MD 20892; e-mail: havlikr{at}gw.nia.nih.gov
The authors assessed the 3-year incidence of dementia, including subtypes, in 2,603 Japanese-American men 71 to 93 years of age who were dementia free at baseline. There were 137 new cases of dementia according to the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised, including 51 with a primary diagnosis of AD. The rates for all subtypes increased with age. Men with an APOE4 allele had a significantly increased risk of AD of 2.39 (95% CI, 1.07, 5.31), after adjusting for age and education. There was no significant relationship of APOE4 with other subtypes of dementia.
Key words: Dementia—Risk factors—Epidemiology
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