| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Departments of Radiology (Drs. Nusbaum and Atlas, and C. Tang) and Psychiatry (C. Tang, T.-C. Wei, and M. Buchsbaum), Mount Sinai School of Medicine, New York, NY; and the Department of Radiology (Dr. Atlas), Stanford University Medical Center, CA.
Address correspondence and reprint requests to Dr. Scott W. Atlas, Department of Radiology, Stanford University Medical Center, S-047, 300 Pasteur Drive, Stanford, CA 94305-5105; e-mail: swatlas{at}stanford.edu
OBJECTIVE: To determine whether quantitative whole-brain MR diffusion histograms in patients with MS differ from those of normal control subjects.
BACKGROUND: MRI detects macroscopic cerebral lesions in MS, but the white matter lesion burden on MRI correlates imperfectly to clinical disability. Previous reports have further suggested abnormalities in white matter of MS patients with no visible lesions on conventional MRI.
METHODS: A total of 25 subjects (13 with MS [9 relapsing–remitting, 4 secondary progressive] and 12 healthy control subjects) underwent diffusion-weighted echoplanar MRI encompassing the entire brain. The average apparent diffusion coefficient (ADCave, or diffusion trace) was calculated on a pixel-by-pixel basis after segmentation of intracranial space from calvarium and extracranial soft tissues. Whole-brain ADCave histograms were calculated and plotted for statistical comparison.
RESULTS: Mean whole-brain MR ADCave in MS patients was elevated and histograms were shifted to higher values compared with normal control subjects. Mean whole-brain ADCave of secondary progressive patients was shifted to higher values compared with relapsing–remitting patients. Whole-brain ADCave histograms of relapsing–remitting patients showed no significant difference from normal control subjects.
CONCLUSION: Whole-brain MR diffusion histograms may quantitate overall cerebral lesion load in patients with MS and may be able to discern differences between clinical subgroups.
Key words: MS—Brain MR—Diffusion MR
This article has been cited by other articles:
|
|
 |
|
  N. ANDREONE, M. TANSELLA, R. CERINI, A. VERSACE, G. RAMBALDELLI, C. PERLINI, N. DUSI, L. PELIZZA, M. BALESTRIERI, C. BARBUI, et al. Cortical white-matter microstructure in schizophrenia: Diffusion imaging study The British Journal of Psychiatry, August 1, 2007; 191(2): 113 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kin, M. Hirano, T. Taoka, Y. Furiya, H. Kataoka, K. Kichikawa, and S. Ueno Global and Region-Specific Analyses of Apparent Diffusion Coefficient in Dentatorubral-Pallidoluysian Atrophy AJNR Am. J. Neuroradiol., August 1, 2006; 27(7): 1463 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rovaris, A. Gass, R. Bammer, S. J. Hickman, O. Ciccarelli, D. H. Miller, and M. Filippi Diffusion MRI in multiple sclerosis Neurology, November 22, 2005; 65(10): 1526 - 1532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Oreja-Guevara, M. Rovaris, G. Iannucci, P. Valsasina, D. Caputo, R. Cavarretta, M. P. Sormani, P. Ferrante, G. Comi, and M. Filippi Progressive Gray Matter Damage in Patients With Relapsing-Remitting Multiple Sclerosis: A Longitudinal Diffusion Tensor Magnetic Resonance Imaging Study Arch Neurol, April 1, 2005; 62(4): 578 - 584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Cassol, J.-P. Ranjeva, D. Ibarrola, C. Mekies, C. Manelfe, M. Clanet, and I. Berry Diffusion tensor imaging in multiple sclerosis: a tool for monitoring changes in normal-appearing white matter Multiple Sclerosis, April 1, 2004; 10(2): 188 - 196. [Abstract] [PDF]
|
|
|
|
|
|
W Rashid, A Hadjiprocopis, C M Griffin, D T Chard, G R Davies, G J Barker, P S Tofts, A J Thompson, and D H Miller Diffusion tensor imaging of early relapsing-remitting multiple sclerosis with histogram analysis using automated segmentation and brain volume correction Multiple Sclerosis, February 1, 2004; 10(1): 9 - 15. [Abstract] [PDF]
|
|
|
|
|
|
E. Adalsteinsson, A. Langer-Gould, R. J. Homer, A. Rao, E. V. Sullivan, C. A. Lima, A. Pfefferbaum, and S. W. Atlas Gray Matter N-Acetyl Aspartate Deficits in Secondary Progressive but Not Relapsing-Remitting Multiple Sclerosis AJNR Am. J. Neuroradiol., November 1, 2003; 24(10): 1941 - 1945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Arzoumanian, M. Mirmiran, P.D. Barnes, K. Woolley, R.L. Ariagno, M.E. Moseley, B.E. Fleisher, and S.W. Atlas Diffusion Tensor Brain Imaging Findings At Term-equivalent Age May Predict Neurologic Abnormalities in Low Birth Weight Preterm Infants AJNR Am. J. Neuroradiol., September 1, 2003; 24(8): 1646 - 1653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rovaris, G. Iannucci, M. Cercignani, M. P. Sormani, N. De Stefano, S. Gerevini, G. Comi, and M. Filippi Age-related Changes in Conventional, Magnetization Transfer, and Diffusion-Tensor MR Imaging Findings: Study with Whole-Brain Tissue Histogram Analysis Radiology, June 1, 2003; 227(3): 731 - 738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. P. Th. Bosma, T. W. J. Huizinga, S. P. Mooijaart, and M. A. van Buchem Abnormal Brain Diffusivity in Patients with Neuropsychiatric Systemic Lupus Erythematosus AJNR Am. J. Neuroradiol., May 1, 2003; 24(5): 850 - 854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cercignani, R. Bammer, M. P. Sormani, F. Fazekas, and M. Filippi Inter-Sequence and Inter-Imaging Unit Variability of Diffusion Tensor MR Imaging Histogram-Derived Metrics of the Brain in Healthy Volunteers AJNR Am. J. Neuroradiol., April 1, 2003; 24(4): 638 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Castriota-Scanderbeg, F. Fasano, G. Hagberg, U. Nocentini, M. Filippi, and C. Caltagirone Coefficient Dav Is More Sensitive Than Fractional Anisotropy in Monitoring Progression of Irreversible Tissue Damage in Focal Nonactive Multiple Sclerosis Lesions AJNR Am. J. Neuroradiol., April 1, 2003; 24(4): 663 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M A Rocca, B Colombo, M Inglese, M Codella, G Comi, and M Filippi A diffusion tensor magnetic resonance imaging study of brain tissue from patients with migraine J. Neurol. Neurosurg. Psychiatry, April 1, 2003; 74(4): 501 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rovaris, M. A Rocca, and M. Filippi Magnetic resonance-based techniques for the study and management of multiple sclerosis Br. Med. Bull., March 1, 2003; 65(1): 133 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Wilson, C R Tench, P S Morgan, and L D Blumhardt Pyramidal tract mapping by diffusion tensor magnetic resonance imaging in multiple sclerosis: improving correlations with disability J. Neurol. Neurosurg. Psychiatry, February 1, 2003; 74(2): 203 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rovaris, M. Bozzali, G. Iannucci, A. Ghezzi, D. Caputo, E. Montanari, A. Bertolotto, R. Bergamaschi, R. Capra, G. L. Mancardi, et al. Assessment of Normal-Appearing White and Gray Matter in Patients With Primary Progressive Multiple Sclerosis: A Diffusion-Tensor Magnetic Resonance Imaging Study Arch Neurol, September 1, 2002; 59(9): 1406 - 1412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C M Griffin, J Dehmeshki, D T Chard, G J. Parker, G J Barker, A J Thompson, and D H Miller T1 histograms of normal-appearing brain tissue are abnormal in early relapsing-remitting multiple sclerosis Multiple Sclerosis, June 1, 2002; 8(3): 211 - 216. [Abstract] [PDF]
|
|
|
|
|
|
M. Filippi and R. I. Grossman MRI techniques to monitor MS evolution: The present and the future Neurology, April 23, 2002; 58(8): 1147 - 1153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Guo, V. L. Jewells, and J. M. Provenzale Analysis of Normal-Appearing White Matter in Multiple Sclerosis: Comparison of Diffusion Tensor MR Imaging and Magnetization Transfer Imaging AJNR Am. J. Neuroradiol., November 1, 2001; 22(10): 1893 - 1900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M Griffin, D. T Chard, O. Ciccarelli, R. Kapoor, G. J Barker, A. J Thompson, and D. H Miller Diffusion tensor imaging in early relapsing-remitting multiple sclerosis Multiple Sclerosis, October 1, 2001; 7(5): 290 - 297. [Abstract] [PDF]
|
|
|
|
|
|
G. Iannucci, M. Rovaris, L. Giacomotti, G. Comi, and M. Filippi Correlation of Multiple Sclerosis Measures Derived from T2-Weighted, T1-Weighted, Magnetization Transfer, and Diffusion Tensor MR Imaging AJNR Am. J. Neuroradiol., September 1, 2001; 22(8): 1462 - 1467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cercignani, M. Inglese, E. Pagani, G. Comi, and M. Filippi Mean Diffusivity and Fractional Anisotropy Histograms of Patients with Multiple Sclerosis AJNR Am. J. Neuroradiol., May 1, 2001; 22(5): 952 - 958. [Abstract] [Full Text]
|
|
|
|
|
|
O. Ciccarelli, D.J. Werring, C.A.M. Wheeler-Kingshott, G.J. Barker, G.J.M. Parker, A.J. Thompson, and D.H. Miller Investigation of MS normal-appearing brain using diffusion tensor MRI with clinical correlations Neurology, April 10, 2001; 56(7): 926 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Wilson, P S Morgan, X Lin, B P Turner, and L D Blumhardt Quantitative diffusion weighted magnetic resonance imaging, cerebral atrophy, and disability in multiple sclerosis J. Neurol. Neurosurg. Psychiatry, March 1, 2001; 70(3): 318 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. O. Nusbaum, C. Y. Tang, M. S. Buchsbaum, T. C. Wei, and S. W. Atlas Regional and Global Changes in Cerebral Diffusion with Normal Aging AJNR Am. J. Neuroradiol., January 1, 2001; 22(1): 136 - 142. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
