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From the Neuromuscular Program, Department of Neurology, The University of New Mexico Health Sciences Center, Albuquerque, NM.
Address correspondence and reprint requests to Dr. Raul N. Mandler, Neuromuscular Program, Department of Neurology, The University of New Mexico Health Sciences Center, ACC-2 -915 Camino de Salud, NE, Albuquerque, NM 87131.
Seven newly diagnosed patients with Devic's neuromyelitis optica were treated with long-term prednisone and azathioprine, and were followed every 2 months for at least 18 months. Their Expanded Disability Status Scale score improved significantly (mean at baseline, 9; mean at 18 months, 3; p < 0.005), and no relapses occurred for more than 18 months. Multicenter controlled studies are needed to prove the efficacy of this therapeutic regimen.
Supported in part by a sabbatical grant to R.N.M.
Received March 19, 1998. Accepted in final form June 5, 1998.
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