| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Departments of Clinical Neurophysiology (Drs. Fernández and Heinze) and Diagnostical Radiology (Drs. Effenberger, Vinz, and Döhring), Otto-von-Guericke University, Magdeburg; and the Departments of Human Genetics (Dr. Steinlein) and Epileptology (Drs. Fernández and Elger), Rheinische-Friedrich-Wilhelms University, Bonn, Germany.
Address correspondence and reprint requests to Dr. Guillén Fernández, Klinik für Epileptologie, Sigmund-Freud-Str. 25, 53105 Bonn, FR Germany.
Objective: One hypothesis proposes that a pre-existing alteration of medial temporal lobe structures contributes to febrile consulsions and subsequent hippocampal sclerosis (HS) in patients with temporal lobe epilepsy (TLE) and antecedent febrile convulsions. It is possible that such a structural alteration does not always lead to convulsions and may also be present in clinically unaffected relatives.
Methods: We tested this hypothesis by MRI investigation of 23 members of two families, of whom 13 had experienced febrile convulsions and 10 had not. One member of each family with febrile consulsions subsequently developed TLE. We compared the right/left ratios of hippocampal volumes (RHV) with 23 age- and sex-matched controls. Additionally, two independent raters assessed hippocampal signal intensity and pattern in T2- and fluid-attenuated inversion recovery images.
Results: Both TLE patients showed left HS. All subjects with febrile convulsions who did not develop epilepsy and six clinically unaffected relatives also showed asymmetric RHV (>3 standard deviation) but a normal hippocampal signal intensity. In all of these subjects, the left hippocampus was smaller. Visual inspection of these smaller hippocampi revealed blurred internal pattern or flat hippocampal bodies or both in one family and smaller hippocampal heads in the other. The pattern of HS in TLE patients showed a structural correlation with the abnormalities seen in their relatives. One subject with febrile convulsions had additional subcortical heterotopias.
Conclusion: These findings suggest a subtle, pre-existing hippocampal malformation that may facilitate febrile convulsions and contribute to the development of subsequent HS.
Supported in part by a personal grant from GlaxoWellcome GmbH and Co. Deutschland to G.F.
Received March 19, 1997. Accepted in final form October 30, 1997.
This article has been cited by other articles:
|
|
 |
|
  A. Labate, A. Cerasa, A. Gambardella, U. Aguglia, and A. Quattrone Hippocampal and thalamic atrophy in mild temporal lobe epilepsy: A VBM study Neurology, September 30, 2008; 71(14): 1094 - 1101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Surges, A Schulze-Bonhage, and D-M Altenmuller Hippocampal involvement in secondarily generalised seizures of extrahippocampal origin J. Neurol. Neurosurg. Psychiatry, August 1, 2008; 79(8): 924 - 929. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shinnar, D. C. Hesdorffer, D. R. Nordli Jr, J. M. Pellock, C. O'Dell, D. V. Lewis, L. M. Frank, S. L. Moshe, L. G. Epstein, A. Marmarou, et al. Phenomenology of prolonged febrile seizures: Results of the FEBSTAT study Neurology, July 15, 2008; 71(3): 170 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kim, N. Bernasconi, B. Bernhardt, O. Colliot, and A. Bernasconi Basal temporal sulcal morphology in healthy controls and patients with temporal lobe epilepsy Neurology, May 27, 2008; 70(22_Part_2): 2159 - 2165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S Briellmann, M. J Hopwood, and G. D Jackson Major depression in temporal lobe epilepsy with hippocampal sclerosis: clinical and imaging correlates J. Neurol. Neurosurg. Psychiatry, November 1, 2007; 78(11): 1226 - 1230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Bien, H. Urbach, J. Schramm, B. M. Soeder, A. J. Becker, R. Voltz, A. Vincent, and C. E. Elger Limbic encephalitis as a precipitating event in adult-onset temporal lobe epilepsy Neurology, September 18, 2007; 69(12): 1236 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Parrini, A. Ramazzotti, W. B. Dobyns, D. Mei, F. Moro, P. Veggiotti, C. Marini, E. H. Brilstra, B. D. Bernardina, L. Goodwin, et al. Periventricular heterotopia: phenotypic heterogeneity and correlation with Filamin A mutations Brain, July 1, 2006; 129(7): 1892 - 1906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dube, C. Richichi, R. A. Bender, G. Chung, B. Litt, and T. Z. Baram Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis Brain, April 1, 2006; 129(4): 911 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M A Montenegro, D Kinay, F Cendes, A Bernasconi, N Bernasconi, A C Coan, L M Li, M M Guerreiro, C A M Guerreiro, I Lopes-Cendes, et al. Patterns of hippocampal abnormalities in malformations of cortical development. J. Neurol. Neurosurg. Psychiatry, March 1, 2006; 77(3): 367 - 371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Labate, P. Ventura, A. Gambardella, E. Le Piane, E. Colosimo, U. Leggio, R. Ambrosio, F. Condino, D. Messina, P. Lanza, et al. MRI evidence of mesial temporal sclerosis in sporadic "benign" temporal lobe epilepsy Neurology, February 28, 2006; 66(4): 562 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Sztriha and A. Gururaj Hippocampal Dysgenesis Associated With Temporal Lobe Hypoplasia and Arachnoid Cyst of the Middle Cranial Fossa J Child Neurol, November 1, 2005; 20(11): 926 - 930. [Abstract] [PDF]
|
|
|
|
|
|
N. Bernasconi, D. Kinay, F. Andermann, S. Antel, and A. Bernasconi Analysis of shape and positioning of the hippocampal formation: an MRI study in patients with partial epilepsy and healthy controls Brain, October 1, 2005; 128(10): 2442 - 2452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Thom, J. Zhou, L. Martinian, and S. Sisodiya Quantitative post-mortem study of the hippocampus in chronic epilepsy: seizures do not inevitably cause neuronal loss Brain, June 1, 2005; 128(6): 1344 - 1357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kakita, S. Kameyama, S. Hayashi, H. Masuda, and H. Takahashi Pathologic Features of Dysplasia and Accompanying Alterations Observed in Surgical Specimens From Patients With Intractable Epilepsy J Child Neurol, April 1, 2005; 20(4): 341 - 350. [Abstract] [PDF]
|
|
|
|
|
|
A. Kakita, S. Kameyama, S. Hayashi, H. Masuda, and H. Takahashi Pathologic Features of Dysplasia and Accompanying Alterations Observed in Surgical Specimens from Patients with Intractable Epilepsy J Child Neurol, March 1, 2004; 19(3): 341 - 350. [Abstract] [PDF]
|
|
|
|
|
|
R. C. Scott, M. D. King, D. G. Gadian, B. G. R. Neville, and A. Connelly Hippocampal abnormalities after prolonged febrile convulsion: a longitudinal MRI study Brain, November 1, 2003; 126(11): 2551 - 2557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Vadlamudi, I E Scheffer, and S F Berkovic Genetics of temporal lobe epilepsy J. Neurol. Neurosurg. Psychiatry, October 1, 2003; 74(10): 1359 - 1361. [Full Text] [PDF]
|
|
|
|
|
|
R. Scott, H. Rantala, and M. Uhari Febrile seizures and mesial temporal sclerosis: No association in a long-term follow-up study Neurology, August 26, 2003; 61(4): 588 - 589. [Full Text] [PDF]
|
|
|
|
|
|
C. Solinas, R. S. Briellmann, A. S. Harvey, L. A. Mitchell, and S. F. Berkovic Hypertensive encephalopathy: Antecedent to hippocampal sclerosis and temporal lobe epilepsy? Neurology, May 13, 2003; 60(9): 1534 - 1536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Janszky, F.G. Woermann, P. Barsi, R. Schulz, P. Halasz, and A. Ebner Right hippocampal sclerosis is more common than left after febrile seizures Neurology, April 8, 2003; 60(7): 1209 - 1210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bocti, Y. Robitaille, P. Diadori, A. Lortie, C. Mercier, A. Bouthillier, and L. Carmant The pathological basis of temporal lobe epilepsy in childhood Neurology, January 28, 2003; 60(2): 191 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tarkka, E. Paakko, J. Pyhtinen, M. Uhari, and H. Rantala Febrile seizures and mesial temporal sclerosis: No association in a long-term follow-up study Neurology, January 28, 2003; 60(2): 215 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Kobayashi, L. M. Li, I. Lopes-Cendes, and F. Cendes Magnetic Resonance Imaging Evidence of Hippocampal Sclerosis in Asymptomatic, First-Degree Relatives of Patients With Familial Mesial Temporal Lobe Epilepsy Arch Neurol, December 1, 2002; 59(12): 1891 - 1894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Grunewald Childhood seizures and their consequences for the hippocampus Brain, September 1, 2002; 125(9): 1935 - 1936. [Full Text] [PDF]
|
|
|
|
 |
|
 S. N. Roper and A. T. Yachnis Book Review: Cortical Dysgenesis and Epilepsy Neuroscientist, August 1, 2002; 8(4): 356 - 371. [Abstract] [PDF]
|
|
|
|
|
|
M. Thom, S. M. Sisodiya, W. R. Lin, T. Mitchell, S. L. Free, J. Stevens, and F. Scaravilli Bilateral isolated hippocampal malformation in temporal lobe epilepsy Neurology, June 11, 2002; 58(11): 1683 - 1686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.D. Gaillard, L. Kopylev, S. Weinstein, J. Conry, P.L. Pearl, M.V. Spanaki, S. Fazilat, S. Fazilat, L.G. Venzina, E. Dubovsky, et al. Low incidence of abnormal 18FDG-PET in children with new-onset partial epilepsy: A prospective study Neurology, March 12, 2002; 58(5): 717 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Briellmann, Y. Torn-Broers, G. D. Jackson, and S. F. Berkovic Seizures in family members of patients with hippocampal sclerosis Neurology, November 27, 2001; 57(10): 1800 - 1804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R A Grunewald, T Farrow, P Vaughan, C D C Rittey, and J Mundy A magnetic resonance study of complicated early childhood convulsion J. Neurol. Neurosurg. Psychiatry, November 1, 2001; 71(5): 638 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Schulz and A. Ebner Prolonged febrile convulsions and mesial temporal lobe epilepsy in an identical twin Neurology, July 24, 2001; 57(2): 318 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kobayashi, I. Lopes-Cendes, C. A. M. Guerreiro, S. C. Sousa, M. M. Guerreiro, and F. Cendes Seizure outcome and hippocampal atrophy in familial mesial temporal lobe epilepsy Neurology, January 23, 2001; 56(2): 166 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M J KOEPP Hippocampal sclerosis: cause or consequence of febrile seizures J. Neurol. Neurosurg. Psychiatry, December 1, 2000; 69(6): 716 - 717. [Full Text]
|
|
|
|
|
|
S. P C Bower, C. J Kilpatrick, S. J Vogrin, K. Morris, and M. J Cook Degree of hippocampal atrophy is not related to a history of febrile seizures in patients with proved hippocampal sclerosis J. Neurol. Neurosurg. Psychiatry, December 1, 2000; 69(6): 733 - 738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dupont, P. F. Van de Moortele, S. Samson, D. Hasboun, J. B. Poline, C. Adam, S. Lehericy, D. Le Bihan, Y. Samson, and M. Baulac Episodic memory in left temporal lobe epilepsy: a functional MRI study Brain, August 1, 2000; 123(8): 1722 - 1732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Sisodiya Surgery for malformations of cortical development causing epilepsy Brain, June 1, 2000; 123(6): 1075 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Liu, S. J. Pleasure, A. E. Collins, J. L. Noebels, F. J. Naya, M.-J. Tsai, and D. H. Lowenstein Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy PNAS, January 18, 2000; 97(2): 865 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. G. Davies, B. D. Bell, B. P. Hermann, and G. Fernandez Hippocampal malformation as a cause of familial febrile convulsions and subsequent hippocampal sclerosis Neurology, May 1, 1999; 52(8): 1717 - 1717. [Full Text]
|
|
|
|
|
|
R. Kuzniecky, S. S. Ho, R. Martin, E. Faught, R. Morawetz, C. Palmer, and F. Gilliam Temporal lobe developmental malformations and hippocampal sclerosis: Epilepsy surgical outcome Neurology, February 1, 1999; 52(3): 479 - 479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Theodore, S. Bhatia, J. Hatta, S. Fazilat, C. DeCarli, S. Y. Bookheimer, and W. D. Gaillard Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures Neurology, January 1, 1999; 52(1): 132 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Jackson, A. M. McIntosh, R. S. Briellmann, and S. F. Berkovic Hippocampal sclerosis studied in identical twins Neurology, July 1, 1998; 51(1): 78 - 84. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
