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The peripheral insulin-like growth factor system in amyotrophic lateral sclerosis and in multiple sclerosis

From the Laboratory of Cellular and Molecular Neuroendocrinology (Dr. Torres-Aleman), Instituto Cajal, CSIC; Division of Pediatric Endocrinology(Dr. Barrios), Hospital del Niño Jesus, Madrid; and Department of Neurology (Dr. Berciano), Hospital Universitario Marques de Valdecilla, Santander, Spain.

Address correspondence and reprint requests to Dr. Ignacio Torres-Aleman, Laboratory of Cellular and Molecular Neuroendocrinology, Cajal Institute, CSIC. Avda. Dr. Arce 37, 28002 Madrid, Spain.

A lack of trophic support may lead to degeneration of adult nerve cells. Several growth factors, including insulin-like growth factor I (IGF-I), control the survival of spinal motor neurons during development as well as after experimental injury. These neurons are selectively affected in patients with amyotrophic lateral sclerosis (ALS). Thus, we analyzes whether reduced levels of circulating IGF-I may be present in this disease. Significant increases were found in three of four of the main circulating IGF-binding proteins in ALS patients, whereas serum IGF-I and insulin levels were significantly reduced. On the contrary, multiple sclerosis patients did not show any significant change in the IGF-I trophic system even though oligodendrocytes are known targets of the trophic action of IGF-I. These results suggest an involvement of the peripheral IGF-I trophic system in ALS.

Supported by grants from Dirección General de Ciencia y Tecnologia(PB94-0097) and Fondo de Investigaciones Sanitarias (94/0401).

Received April 8, 1997. Accepted in final form September 29, 1997.

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