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From the Gertrude H. Sergievsky Center (Drs. Hesdorffer, Logroscino, and Hauser), Department of Neurology, Division of Epidemiology, School of Public Health, Columbia University, New York, NY; the Divisione de Neurologia(Dr. Logroscino), Ospedale Miulli Acquaviva, Bari, Italy; the Department of Neurology and Health Sciences Research (Drs. Hesdorffer, Cascino, Annegers, and Hauser), Mayo Clinic and Mayo Foundation, Rochester, MN; and University of Texas School of Public Health (Dr. Annegers), Houston, TX.
Address correspondence and reprint requests to Dr Hesdorffer, G.H. Sergievsky Center, 630 West 168th Street, P&S Box 16, New York, NY 10032.
We determined the incidence of status epilepticus (SE) by ascertaining all first episodes of SE in Rochester, Minnesota through the Rochester Epidemiology Project's records-linkage system between January 1, 1965 and December 31, 1984. Information was collected on age, gender, duration, seizure type, and etiology. The age-adjusted incidence of SE was 18.3 per 100,000 population. SE incidence was U-shaped, peaking under 1 year and over 60 years of age. The incidence of SE was greater for males than for females, for acute symptomatic etiology than any other etiology, and for partial SE that did not generalize than any other seizure type. Status of long duration(at least 2 hours) occurred more frequently among infants and the elderly than among persons aged 1 to 65 years. Cumulative incidence was 4 per 1,000 to age 75 and showed the greatest increase after age 60. Given the aging of the population, SE will become an increasingly important public health problem.
Supported in part through grants from NINDS (5-P50-NS-16308) to the University of Minnesota and NIH (MO1RR00645) to Columbia University.
Received May 29, 1997. Accepted in final form November 22, 1997.
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