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NEUROLOGY 1998;50:604-609
© 1998 American Academy of Neurology

Oculomotor abnormalities in schizophrenia

A critical review

Sam Hutton, DPhil and Christopher Kennard, PhD FRCP

From the Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, London, United Kingdom.

Address correspondence and reprint requests to Prof. Christopher Kennard, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, Fulham Palace Road, London, W6 8RF, United Kingdom.

Oculomotor abnormalities, particularly in smooth pursuit tracking, are one of the most widely investigated biological markers of schizophrenia. However, despite the wealth of published data, important questions concerning the exact nature of these abnormalities remain unanswered. Many of the studies use unreliable methodology, and few attempts have been made to interpret the observed oculomotor dysfunction in terms of current understanding of eye movement physiology. Also, the potential effects of antipsychotic medication have been poorly addressed. Recent research, using more reliable measurement techniques and novel saccadic paradigms are producing important results and may provide a more productive framework for future studies of oculomotor abnormalities in schizophrenia.

Supported by the Wellcome Trust.

Received February 22, 1997. Accepted in final form September 12, 1997.






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