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NEUROLOGY 1995;45:1735-1738
© 1995 American Academy of Neurology

Positron emission tomography study of human narcolepsy

No increase in striatal dopamine D2 receptors

J. O. Rinne, MD, C. Hublin, MD, M. Partinen, MD, H. Ruottinen, MD, U. Ruotsalainen, MSc, K. Nagren, PhD, P. Lehikoinen, PhD and A. Laihinen, MD

From the Department of Neurology (Drs. Rinne, Ruottinen, and Laihinen), University of Turku; the Department of Neurology (Drs. Hublin and Partinen), University of Helsinki; University of Turku PET Center (U. Ruotsalainen), PET Unit; and University of Turku PET Center (Drs. Nagren and Lehikoinen), Radiopharmaceutical Chemistry Laboratory, Finland.
Supported by the Medical Research Council of the Academy of Finland.
Received September 9, 1994. Accepted in final form February 10, 1995.
Address correspondence and reprint requests to Dr. Juha O. Rinne, Department of Neurology, University of Turku, FIN-20520 Turku, Finland.

We investigated dopamine D2 receptors in the caudate nucleus and putamen with positron emission tomography in seven patients with narcolepsy and seven healthy controls by using [(11) C]raclopride as a ligand.We applied an equilibrium method and Scatchard principle to give a quantitative estimation of the number (Bmax) and dissociation constant (Kd) of the receptors. Both the Bmax and Kd were within the normal range in the caudate nucleus and putamen in narcoleptic patients. We found no evidence for increased D2 receptor binding in narcolepsy.






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