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Progesterone therapy in women with complex partial and secondary generalized seizures

From the Neuroendocrine Unit, Charles A. Dana Research Institute, Beth Israel Hospital, and the Department of Neurology, Harvard Medical School, Boston, MA.
Presented in part at the 118th annual meeting of the American Neurological Association, October 19, 1993.
Received November 15, 1994. Accepted in final form January 28, 1995.
Address correspondence and reprint requests to Dr. Andrew G. Herzog, Neuroendocrine Unit, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215.

This open trial assessed the effects of adjunctive progesterone therapy on seizure frequency in 25 women with catamenial exacerbation of complex partial (CPS) and secondary generalized motor (SGMS) seizures.Progesterone was well tolerated by 23 of the 25 women and had readily reversible dose-related side effects of asthenia and emotional depression in two. Eighteen women (72%) experienced a decline in seizure frequency during a 3-month treatment period compared with the 3 months prior to therapy (p less than 0.01). Average daily CPS frequency declined by 54% (p less than 0.01), SGMS by 58% (p less than 0.02).

NEUROLOGY 1995;45: 1660-1662