Clinical features and pathophysiologic mechanisms of postherpetic neuralgia
Postherpetic neuralgia is an unfortunate aftermath of shingles,and is most likely to develop, and most persistent, in elderlypatients.Pain, allodynia, and sensory loss in the affected dermatomeare the cardinal manifestations of the disorder. The pathophysiologyof postherpetic neuralgia is not well known, but recent observationssuggest multiple changes in the afferent pathways at both peripheraland central nervous system levels.
NEUROLOGY 1995;45(Suppl 8): S54-S55
From the Department of Neurology, Tampere University Hospital,Tampere, Finland, and the Walton Centre for Neurology and NeurosurgeryNHS Trust, Liverpool, UK.