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Cytokine production in varicella-zoster virus-stimulated lymphocyte cultures

From the Departments of Pediatrics and Medicine (Drs. Zhang, Levin, and Hayward), University of Colorado School of Medicine, Denver, CO; and Merck Research Laboratories (Dr. White), West Point, PA.
Supported in part by a grant from the NCRR General Clinical Research Centers Program, RR69.
Address correspondence and reprint requests to Dr. Anthony Hayward, University of Colorado School of Medicine, 4200 E. 9th Avenue, Box B140, Denver, CO 80262.

Among varicella-zoster virus (VZV)-immune adults aged 20 to 35 years, T lymphocytes producing interferon- gamma (IFN- gamma) in response to a VZV antigen stimulus are eight times more numerous than those making interleukin-4 (IL-4). In persons over 55 years old, the frequency of IFN- gamma -making cells falls while the number of IL-4-making cells remains roughly constant. The persistence of IL-4-making cells may contribute to the maintenance of IgG antibodies to VZV with aging.

NEUROLOGY 1995;45(Suppl 8): S38-S40