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NEUROLOGY 1995;45:S33-S35
© 1995 American Academy of Neurology

Transcriptional mapping of varicella-zoster virus regulatory proteins

Paul R. Kinchington, PhD, Jean-Paul MA Vergnes and Stephanie E. Turse, BS

From the Departments of Ophthalmology and Molecular Genetics and Biochemistry, University of Pittsburgh, PA.
Supported by Public Health Service grant EY 09397 and a CORE Grant for Vision Research (EY 08098).
Address correspondence and reprint requests to Dr. Paul R. Kinchington, Department of Ophthalmology, 1020 Eye and Ear Institute, University of Pittsburgh, 203 Lothrop Street, Pittsburgh, PA 15213.

Varicella-zoster virus (VZV) expresses four proteins that influence viral transcriptional events and that also are homologous to herpes simplex virus type 1 (HSV-1) immediate-early proteins. However, their transcription and the mechanisms by which it is regulated are not yet resolved. To identify the promoter regions, a precise knowledge of the initiation and termination of the encoded RNAs is first required. In this report, we summarize the complete and precise mapping of the RNA transcripts of two of these genes-those from open reading frames 4 and 63. In addition, several elements of their promoter regulatory regions have been identified and predicted. Structural and functional studies of the regulatory sequences suggest that these two VZV genes may be regulated in a fashion different from that of their HSV-1 counterparts.

NEUROLOGY 1995;45(Suppl 8): S33-S35)






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