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NEUROLOGY 1995;45:S23-S27
© 1995 American Academy of Neurology

Varicella-zoster virus gene regulation

J. Piette, PhD, P. Defechereux, MSc, L. Baudoux, MSc, S. Debrus, MSc, M. P. Merville, PhD and B. Rentier, PhD, DSc

From the Laboratory of Virology, Department of Microbiology, Institute of Pathology, University of Liege, Liege, Belgium.
J.P. is Research Director at the Belgian National Fund for Scientific Research (BNFSR, Brussels, Belgium), P.D. is supported by a SmithKline Beecham-BNFSR grant, L.B. is supported by a grant from the Anti-Cancer Research Fund (Liege, Belgium), and S.D. is a grantee of the IRSIA (Brussels, Belgium). VZV research programs in our laboratory are supported by the BNFSR, SmithKline Beecham (Rixensart, Belgium), the VZV Research Foundation (New York. NY), and the Belgian National Lottery.
Address correspondence and reprint requests to Dr. Jacques Piette, Laboratory of Virology, Department of Microbiology, Institute of Pathology, B23 University of Liege, B-4000, Liege, Belgium.

The varicella-zoster virus genome contains 71 open reading frames (ORFs), five of which (ORF62, ORF4, ORF63, ORF61, and ORF10) encode regulatory proteins. ORF62 codes for the major immediate early protein of the virus exhibiting DNA-binding and regulatory functions. This protein, localized in the cell nucleus, is a functional homologue to ICP4 of herpes simplex virus type 1 (HSV-1). It trans-activates several varicella-zoster virus promoters of the various gene classes and autoregulates its own expression. ORF4 protein activates gene promoters provided they have basal activities, but it is not a functional homologue of HSV-1 ICP27. Gene regulation activity appears to be linked to its cysteine-rich C-terminal region. ORF63 codes for an immediate early protein mainly located in the cell nucleus. The regulatory functions it performs are still unclear. ORF61 protein is the functional homologue of HSV-1 ICP0. Its N-terminal region exhibits a RING domain responsible for trans-activating and trans-repressing activities. ORF10 protein exhibits similarities with HSV-1 VP16 and activates the ORF62 promoter.

NEUROLOGY 1995;45(Suppl 8): S23-S27






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