Neurology
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Neurology, Vol 45, Issue 11 2015-2017, Copyright © 1995 by American Academy of Neurology

ARTICLES

Chronic myelopathy associated with human herpesvirus-6

IR Mackenzie, DR Carrigan and CA Wiley
Department of Pathology (Neuropathology), University of Western Ontario, London, Canada.

Human herpesvirus-6 (HHV-6) is implicated in a variety of neurologic diseases. We report a previously healthy elderly woman with progressive spastic paraparesis. At autopsy the spinal cord showed widespread demyelination, axonal loss, and chronic inflammation. HHV-6 DNA was amplified, using polymerase chain reaction, from spinal cord tissue, and glial cells were immunoreactive with an HHV-6 antibody. These findings suggest that HHV-6 may cause myelopathy.


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