Neurology
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Neurology, Vol 45, Issue 11 2005-2009, Copyright © 1995 by American Academy of Neurology

ARTICLES

Primary lateral sclerosis: a neuropsychological study

RJ Caselli, BE Smith and D Osborne
Department of Neurology, Mayo Clinic Scottsdale, AZ 85259, USA.

Nine patients with clinically diagnosed, radiologically supported primary lateral sclerosis underwent cognitive testing. None was demented, but eight had mild cognitive impairment. Performances were most consistently impaired on neuropsychological tests sensitive to frontal lobe functions, followed by tests sensitive to memory. Cognitive testing may be useful in helping to establish a cortical localization in patients with the syndrome of progressive spasticity. There are potential nosologic relations between primary lateral sclerosis and other degenerative frontal lobe syndromes, such as frontal lobe dementia and progressive spasticity with dementia.




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