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NEUROLOGY 1994;44:1523
© 1994 American Academy of Neurology

Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis

P. Rieckmann, MD, M. Albrecht, BA, B. Kitze, MD, T. Weber, MD, H. Tumani, MD, A. Broocks, MD, W. Lüer, MD and S. Poser, MD

Laboratory of Neurobiology, Departments of Neurology and Psychiatry, University of Göttingen, Germany.

We determined the cytokine messenger RNA (mRNA) expression pattern of blood mononuclear cells in 45 patients with the relapsing-remitting form of MS and 32 patients with other neurologic diseases. Using a semiquantitative polymerase chain reaction method, we detected significantly higher levels of tumor necrosis factor-alpha and lymphotoxin mRNA in patients with relapsing compared to those with stable disease (p < 0.001), but transforming growth factor-beta and interleukin-10 mRNA expressions were higher in patients with stable disease.

Address correspondence and reprint requests to Dr. P. Rieckmann, Department of Neurology, University of Göttingen, Robert Koch Str. 40, 37075 Göttingen, Germany.

Supported by grants from the Hertie-Stiftung (GHS 204/91), Deutsche Multiple Sklerose Gesellschaft and Deutsche Forschungsgemeinschaft (DFG Az Ri 516-2/1).

Received November 15, 1993. Accepted in final form February 1, 1994.






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