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NEUROLOGY 1994;44:1432
© 1994 American Academy of Neurology

Meige syndrome in the spectrum of Lewy body disease

M. H. Mark, MD, J. I. Sage, MD, D. W. Dickson, MD, R. E. Heikkila, PhD, L. Manzino, BA, K. O. Schwarz, MD and R. C. Duvoisin, MD

Departments of Neurology (Drs. Mark, Sage, Heikkila, and Duvoisin, and Mr. Manzino) and Pathology (Neuropathology) (Dr. Schwarz), University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ; and the Departments of Pathology (Neuropathology) and Neurology (Dr. Dickson), Albert Einstein College of Medicine, Bronx, NY.

We report a patient with Meige syndrome (segmental cranial dystonia) who had neuropathology changes of Parkinson's disease on postmortem examination. Neuropathologic examination showed typical and atypical Lewy bodies in the pigmented nuclei of the brainstem (substantia nigra, locus ceruleus), the nucleus basalis of Meynert, and the nucleus ambiguus. Neurochemical analysis of postmortem brain tissue showed evidence for decreased dopamine turnover in the substantia nigra, striatum, and nucleus accumbens. We propose that some cases of Meige syndrome may be included in the spectrum of Lewy body disease.

Address correspondence and reprint requests to Dr. Margery H. Mark, Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, CN-19, New Brunswick, NJ 08903.

{dagger} Deceased.

Presented in part at the 42nd annual meeting of the American Academy of Neurology, Miami Beach, FL, May 1990.

Received November 23, 1993. Accepted in final form January 26, 1994.




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N. Tabet and S. Sivaloganathan
Meige's syndrome in dementia with Lewy bodies
J R Soc Med, January 4, 2002; 95(4): 201 - 202.
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