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NEUROLOGY 1994;44:1153
© 1994 American Academy of Neurology

Serum levels of soluble E-selectin (ELAM-1) in immune-mediated neuropathies

H.-P. Hartung, MD, K. Reiners, MD, M. Michels, MD, R.A.C. Hughes, MD, FRCP, F. Heidenreich, MD, J. Zielasek, MD, U. Enders, MD and K. V. Toyka, MD

Department of Neurology (Drs. Hartung, Reiners, Michels, Zielasek, Enders, and Toyka), Julius-Maximilians-Universität, Würzburg, Germany; Department of Neurology (Dr. Hughes), United Medical and Dental Schools, Guy's Hospital, London, UK, and the Department of Neurology (Dr. Heidenreich), Heinrich-Heine-Universität, Düsseldorf, Germany.

Adhesion molecules are critically involved in inflammatory responses. We studied serum concentrations of the soluble form of E-selectin (endothelial-leukocyte adhesion molecule-1, ELAM-1) in 187 patients with neuropathies of diverse etiology, 54 patients with other noninflammatory, nondemyelinating neurologic disorders, and 15 healthy controls. Serum E-selectin levels, quantitated by a two-site enzyme-linked immunosorbent assay, were significantly increased in 126 patients with Guillain-Barré syndrome (GBS) (mean ± SD, 45.1 ± 16.3 ng/ml) and 13 patients with vasculitic neuropathies (47.1 ± 19.1 ng/ml) compared with patients with other neurologic diseases (19.8 ± 7.4 ng/ml) and healthy controls (21.9 ± 8.1 ng/ml). In GBS, E-selectin levels were temporally related to disease activity. Cytokine-mediated upregulation of E-selectin may be important in homing and attachment of leukocytes to en-doneurial endothelial cells. Raised E-selectin concentrations probably reflect endothelial cell activation occurring early in the sequence of immunopathologic events culminating in peripheral nerve damage.

Address correspondence and reprint requests to Dr. Hans-Peter Hartung, Department of Neurology, Julius-Maximilians-Universität, Josef-Schneider-Strasse 11,97080 Würzburg, Germany.

Supported in part by grants from Bundesministerium für Forschung und Technologie (01 KD 9000118 and 01 KD 8903-30).

Received September 30,1993. Accepted for publication in final form November 23, 1993.




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