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NEUROLOGY 1994;44:1051
© 1994 American Academy of Neurology

Parkinsonism caused by petroleum waste ingestion

James W. Tetrud, MD, J. William Langston, MD, Ian Irwin, BA, BS and Barry Snow, MD

Parkinson's Institute (Drs. Tetrud and Langston and I. Irwin), Sunnyvale, CA; and the University of British Columbia (Dr. Snow), Vancouver, BC, Canada.

A 20-year-old laborer developed moderate parkinsonism 1 week after accidentally ingesting a petroleum waste mixture. Parkinsonism persisted for 3 months and then began to improve, although subtle signs remained 29 months after exposure. 6-Fluorodopa-labeled positron emission tomography (6-FD PET) performed 3 months postexposure revealed a striatal dopamine rate constant level of 0.170 ml/striatum/min, nearly 3 SD below the mean for age-matched controls. However, subsequent PETs demonstrated 6-FD PET rate constants not significantly different than controls. Although the causative agent has not yet been identified, this case suggests that compounds capable of causing parkinsonism may exist in commonly used petroleum products.

Address correspondence and reprint requests to Dr. James W. Tetrud, Parkinson's Institute, 1170 Morse Avenue, Sunnyvale, CA 94089-1605.

Supported by the Parkinson's Institute.

Received August 17, 1993. Accepted for publication in final form December 22, 1993.




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