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Uhthoff's symptom in disorders of the anterior visual pathways

Department of Neurology, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School, New Brunswick, NJ.

To determine the frequency and clinical characteristics of Uhthoff s symptom, I studied 100 consecutive patients with pregeniculate visual loss of diverse etiology. Eighteen patients reported Uhthoff's symptom. Although there was a significant association of Uhthoff's symptom with multiple sclerosis (10 patients), other etiologies for this symptom included tumor (3 patients), optic neuropathy or papillitis (3 patients), aneurysm, and orbital pseudotumor (1 patient each). There was no link between the severity of visual loss, as measured by diminished acuity, field loss, or binocular involvement, and Uhthoff's symptom.

Address correspondence and reprint requests to Dr. Frederick E. Lepore, Department of Neurology, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School, New Brunswick, NJ 08903-0019.

Presented in part a t the 45th annual meeting of the American Academy of Neurology, New York, NY, April 1993.

Received September 30, 1993. Accepted for publication in final form November 22, 1993.