NEUROLOGY 1994;44:884
© 1994 American Academy of Neurology
Akinesia in Parkinson's disease. I. Shortening of simple reaction time with focal, single-pulse transcranial magnetic stimulation
A. Pascual-Leone, MD, PhD,
J. Valls-Solé, MD, PhD,
J. P. Brasil-Neto, MD,
L. G. Cohen, MD and
M. Hallett, MD
Human Cortical Physiology Unit, Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
Article abstract –We studied the effects of transcranial magnetic stimulation (TMS) of the motor cortex on simple reaction time (RT) in 10 patients with Parkinson's disease compared with 10 age-matched normal controls. The subjects flexed their right elbow rapidly in response to a visual go-signal. In random trials, TMS was applied to the left motor cortex at varying delays after the go-signal. In trials without TMS, RT was longer in the patients. However, in the trials with subthreshold TMS, RT in the patients became as fast as RT in trials without TMS in the controls. This shortening was associated with normalization of the voluntary triphasic EMG pattern and the pre-movement cortical excitability increase.
Address correspondence and reprint requests to Dr. Mark Hallett, Building 10, Room 5N226, NINDS, NIH, Bethesda, MD 20892.
Received December 27, 1991. Accepted for publication in final form October 26, 1993.
This article has been cited by other articles:
|
|
|
|
 
F Fregni, D K Simon, A Wu, and A Pascual-Leone
Non-invasive brain stimulation for Parkinson's disease: a systematic review and meta-analysis of the literature
J. Neurol. Neurosurg. Psychiatry,
December 1, 2005;
76(12):
1614 - 1623.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Kleiner-Fisman, D. N. Fisman, F. I. Kahn, E. Sime, A. M. Lozano, and A. E. Lang
Motor Cortical Stimulation for Parkinsonism in Multiple System Atrophy
Arch Neurol,
November 1, 2003;
60(11):
1554 - 1558.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Gilio, A. Curra, M. Inghilleri, C. Lorenzano, A. Suppa, M. Manfredi, and A. Berardelli
Abnormalities of motor cortex excitability preceding movement in patients with dystonia
Brain,
August 1, 2003;
126(8):
1745 - 1754.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Low, J. Miller, and E. Vierck
Response slowing in Parkinson's disease: A psychophysiological analysis of premotor and motor processes
Brain,
September 1, 2002;
125(9):
1980 - 1994.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Baron, T. Wichmann, D. Ma, and M. R. DeLong
Effects of Transient Focal Inactivation of the Basal Ganglia in Parkinsonian Primates
J. Neurosci.,
January 15, 2002;
22(2):
592 - 599.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Berardelli, J. C. Rothwell, P. D. Thompson, and M. Hallett
Pathophysiology of bradykinesia in Parkinson's disease
Brain,
November 1, 2001;
124(11):
2131 - 2146.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Sommer, J. Classen, L. G. Cohen, and M. Hallett
Time Course of Determination of Movement Direction in the Reaction Time Task in Humans
J Neurophysiol,
September 1, 2001;
86(3):
1195 - 1201.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. George, S. H. Lisanby, and H. A. Sackeim
Transcranial Magnetic Stimulation: Applications in Neuropsychiatry
Arch Gen Psychiatry,
April 1, 1999;
56(4):
300 - 311.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. George, E. M. Wassermann, T. A. Kimbrell, J. T. Little, W. E. Williams, A. L. Danielson, B. D. Greenberg, M. Hallett, and R. M. Post
Mood Improvement Following Daily Left Prefrontal Repetitive Transcranial Magnetic Stimulation in Patients With Depression: A Placebo-Controlled Crossover Trial
Am J Psychiatry,
December 1, 1997;
154(12):
1752 - 1756.
[Abstract]
[Full Text]
|
|
|
|
