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Department of Neurosciences Unit, Institute of Child Health, London, UK. (Drs. Jackson and Cross)
Department of Radiology and Physics Unit, Institute of Child Health, London, UK. (Drs. Connelly and Gadian)
Department of Radiology (Dr. Gordon), Hospital for Sick Children, Great Ormond Street, London, UK.
Article abstract –Magnetic resonance imaging (MRI) can now provide maps of human brain function with high spatial and temporal resolution. We aimed to establish whether this noninvasive technique could also map the cortical activation that occurs during focal seizures. In order to do this, we used a conventional 1.5-tesla clinical MRI system for the investigation of a 4-year-old boy suffering from frequent partial motor seizures of his right side. We acquired FLASH images (TE = 60 msec) every 10 seconds over intervals of 10 minutes and derived activation images by subtracting baseline images from images obtained during clinical seizures. Functional MRI revealed sequential activation associated with specific gyri within the left hemisphere with each of five consecutive clinical seizures, and also during a period that was not associated with a detectable clinical seizure. The activated regions included gyri that were structurally abnormal. We concluded that functional MRI can provide new insights into the dynamic events that occur in the epileptic brain and their relationship to brain structure.
Address correspondence and reprint requests to Prof. David G. Gadian, Radiology and Physics Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom.
We are grateful to the Wellcome Trust and Action Research for support
Received August 20, 1993. Accepted for publication in final form October 26, 1993.
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