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Abnormal connectivity of the visual pathways in human albinos demonstrated by susceptibility-sensitized MRI

Alzheimer Center, Department of Neurology (Drs. Hedera, Lerner, and Friedland), University Hospitals of Cleveland; Department of Physics (Drs. Lai and Haacke), Case Western Reserve University, Cleveland; Department of Anatomy (Dr. Hopkins), Case Western Reserve University; and Department of Radiology (Drs. Haacke and Lewin), University Hospitals of Cleveland, OH.

We studied activation of the human visual cortex (VC) using susceptibility-sensitized MRI at 1.5 Tesla. Three albinos and six healthy controls underwent a series of monocular and binocular photic flash stimulation. Monocular stimulation in albinos caused predominant contralateral activation with a small, well-delineated area in the anterior part of the VC in the ipsilateral hemisphere. This finding was consistent with a chiasmal crossing anomaly in albinism. All controls had symmetric patterns of activation during monocular stimulation. Functional MEI represents a promising method for evaluation of the visual pathways in humans.

Address correspondence and reprint requests to Dr. R.P. Friedland, 11100 Euclid Avenue, Cleveland, OH 44106.

Deceased.

Supported in part by NIH grant AG 08012-05 and Philip Morris, USA.

Received November 3, 1993. Accepted in final form March 16, 1994.

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