| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Danish Institute for Clinical Epidemiology and Danish Multiple Sclerosis Registry, Copenhagen, Denmark.
We estimated survival probability and excess death rates for patients with MS on the basis of data from the Danish Multiple Sclerosis Registry, which includes virtually all patients diagnosed with MS in Denmark (population, five million) since 1948. We reviewed and reclassified all case records according to standardized diagnostic criteria. By linkage to the Danish Central Population Registry, we lost to follow-up only 25 patients who had emigrated. The median survival time from onset of the disease was 28 years in men (compared with 40 years in the matched general male population) and 33 years in women (versus 46 years). The median survival time from diagnosis was 22 years in men (versus 37 years) and 28 years in women (versus 42 years). The excess death rate between onset and follow-up (observed deaths per 1,000 person-years minus the expected number of deaths in a matched general population) was 14.3 in men, which was significantly higher than in women (12.0). Excess mortality increased with age at onset of MS in people of each sex. The 10-year excess death rate has decreased significantly in recent decades. Excess mortality was highest in cases with cerebellar symptoms at onset.
Address correspondence and reprint requests to Mr. Henrik Brønnum-Hansen, The Danish Institute for Clinical Epidemiology, Svanemøllevej 25, DK-2100 Copenhagen 
, Denmark.
The Danish Multiple Sclerosis Registry is subsidized by the Danish Multiple Sclerosis Association.
Received June 10, 1993. Accepted in final form March 18, 1994.
This article has been cited by other articles:
|
|
 |
|
  A. L. Barnard, A. P. Chidgey, C. C. Bernard, and R. L. Boyd Androgen depletion increases the efficacy of bone marrow transplantation in ameliorating experimental autoimmune encephalomyelitis Blood, January 1, 2009; 113(1): 204 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Hirst, G Ingram, R Swingler, D A S Compston, T Pickersgill, and N P Robertson Change in disability in patients with multiple sclerosis: a 20-year prospective population-based analysis J. Neurol. Neurosurg. Psychiatry, October 1, 2008; 79(10): 1137 - 1143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Hirst, R Swingler, D A S Compston, Y Ben-Shlomo, and N P Robertson Survival and cause of death in multiple sclerosis: a prospective population-based study J. Neurol. Neurosurg. Psychiatry, September 1, 2008; 79(9): 1016 - 1021. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Leray, S. Morrissey, J. Yaouanq, M. Coustans, E. Le Page, J. Chaperon, and G. Edan Long-term survival of patients with multiple sclerosis in West France Multiple Sclerosis, August 1, 2007; 13(7): 865 - 874. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Bronnum-Hansen, N. Koch-Henriksen, and E. Stenager Trends in survival and cause of death in Danish patients with multiple sclerosis Brain, April 1, 2004; 127(4): 844 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Pittock, W. T. Mayr, R. L. McClelland, N. W. Jorgensen, S. D. Weigand, J. H. Noseworthy, B. G. Weinshenker, and M. Rodriguez Change in MS-related disability in a population-based cohort: A 10-year follow-up study Neurology, January 13, 2004; 62(1): 51 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M-L Sumelahti, P J Tienari, J Wikstrom, T M Salminen, and M Hakama Survival of multiple sclerosis in Finland between 1964 and 1993 Multiple Sclerosis, August 1, 2002; 8(4): 350 - 355. [Abstract] [PDF]
|
|
|
|
|
|
A Solari, L Mancuso, A Motta, L Mendozzi, and C Serrati Comparison of two brief neuropsychological batteries in people with multiple sclerosis Multiple Sclerosis, April 1, 2002; 8(2): 169 - 176. [Abstract] [PDF]
|
|
|
|
|
|
K M Myhr, T Riise, C Vedeler, M W Nortvedt, M Gronning, R Midgard, and H I Nyland Disability and prognosis in multiple sclerosis: demographic and clinical variables important for the ability to walk and awarding of disability pension Multiple Sclerosis, February 1, 2001; 7(1): 59 - 65. [Abstract] [PDF]
|
|
|
|
|
|
M. T. Wallin, W. F. Page, and J. F. Kurtzke Epidemiology of multiple sclerosis in US veterans VIII. Long-term survival after onset of multiple sclerosis Brain, August 1, 2000; 123(8): 1677 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. G Weinshenker Databases in MS research: pitfalls and promises Multiple Sclerosis, August 1, 1999; 5(4): 206 - 211. [Abstract] [PDF]
|
|
|
|
|
|
T. L. Sorensen, J. L. Frederiksen, H. Bronnum-Hansen, and H. C. Petersen Optic neuritis as onset manifestation of multiple sclerosis: A nationwide, long-term survey Neurology, August 1, 1999; 53(3): 473 - 473. [Abstract] [Full Text]
|
|
|
|
|
|
N. Koch-Henriksen, H. Brønnum-Hansen, and E. Stenager Underlying cause of death in Danish patients with multiple sclerosis: results from the Danish Multiple Sclerosis Registry J. Neurol. Neurosurg. Psychiatry, July 1, 1998; 65(1): 56 - 59. [Abstract] [Full Text]
|
|
|
|
|
|
H Carton, R Loos, J Pacolet, K Versieck, and R Vlietinck Utilisation and cost of professional care and assistance according to disability of patients with multiple sclerosis in Flanders (Belgium) J. Neurol. Neurosurg. Psychiatry, April 1, 1998; 64(4): 444 - 450. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
