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NEUROLOGY 1994;44:1845
© 1994 American Academy of Neurology

Left temporal neocortex mediation of verbal memory

Evidence from functional mapping with cortical stimulation

Kenneth Perrine, PhD, Orrin Devinsky, MD, Suzan Uysal, PhD, Daniel J. Luciano, MD and Michael Dogali, MD

Departments of Neurology (Drs. Perrine, Devinsky, Uysal, and Luciano) and Neurosurgery (Dr. Dogali), NYU School of Medicine and the Hospital for Joint Diseases, New York, NY.

We examined the contribution of the temporal neocortex to short-term memory (STM) in 15 patients with left hemisphere language dominance during intraoperative or extraoperative cortical mapping prior to left anterior temporal lobectomy. Recall errors were examined following stimulation during the acquisition, consolidation, and retrieval stages of a verbal STM task. Ten patients showed stimulation-induced recall errors, and five patients showed no significant memory errors. More patients showed errors following stimulation during consolidation than during acquisition or retrieval, possibly because of disrupted transfer of information from the temporal neocortex to the hippocampus. Patients with stimulation-induced recall errors did not differ significantly from patients without memory errors in terms of seizure, demographic, or neuropsychological variables. Patients with resection of sites showing stimulation-induced recall errors had greater postoperative decline in verbal memory than did patients with resection sparing these sites. We suggest that the left temporal neocortex contributes to verbal memory consolidation in patients with chronic epilepsy.

Address correspondence and reprint requests to Dr. Kenneth Perrine, Department of Neurology, Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003.

Received June 28, 1993. Accepted in final form March 30, 1994.




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