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Material-specific memory in the intracarotid amobarbital procedure

Department of Neurology (Drs. Perrine, Gershengorn, Brown, Luciano, and Devinsky), NYU School of Medicine and Hospital for Joint Diseases, and the Department of Neuroradiology (Dr. Choi), NYU School of Medicine, New York, NY.

We examined material-specific memory in 45 left hemisphere language dominant patients with temporal complex partial seizures (24 right, 21 left) during the intracarotid amobarbital procedure (IAP) by showing eight cards displaying two line drawings of common objects, two printed words, one colored shape, one math expression, one face, and one abstract shape following amobarbital injection (mean = 109.9 mg). We assessed delayed recall and recognition following clearing. Patients with right foci recognized significantly fewer verbally mediated stimuli (words, object drawings, colored shape) with left than with right injection. Patients with left foci recognized a nonverbal stimulus (abstract shape) more poorly following right versus left injection. Discriminant function analysis lateralized 85% of the sample from memory predictors, upheld to 81% on crossvalidation. Material-specific memory remains intact in the hemisphere contralateral to a seizure focus, but wider representation may occur for stimuli normally dominant for the hemisphere with the seizure focus. The IAP significantly lateralizes a seizure focus with use of both types of stimuli.

Presented in part at the annual meeting of the American Epilepsy Society, Philadelphia, PA, December 1991.

Address correspondence and reprint requests to Dr. Kenneth Perrine, Department of Neurology, Hospital for Joint Diseases, 301 E. 17th Street, New York, NY 10003.

Received June 4, 1992. Accepted for publication in final form August 31, 1992.

This article has been cited by other articles:

				K. Perrine, O. Devinsky, D. J. Luciano, I. S. Choi, and P. K. Nelson Correlates of Arterial-Filling Patterns in the Intracarotid Amobarbital Procedure Arch Neurol, July 1, 1995; 52(7): 712 - 716. [Abstract] [PDF]