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NEUROLOGY 1992;42:1740
© 1992 American Academy of Neurology

Periodic alternating gaze deviation in infancy

Richard H. Legge, MD, Howard S. Weiss, MD, Thomas R. Hedges, III, MD and Mary L. Anderson, MD

Departments of Ophthalmology, New England Medical Center, Tufts University, Boston, MA (Drs. Legge, Weiss, and Hedges)
Departments of Neurology, New England Medical Center, Tufts University, Boston, MA (Dr. Hedges)
Departments of Neuroradiology, New England Medical Center, Tufts University, Boston, MA (Dr. Anderson).

Periodic alternating gaze is a rarely reported phenomenon. We have observed two cases that are unique in their early onset at birth and infancy. Multiple congenital defects of the posterior cranial fossa were present on MRI in both cases. A prominent abnormality shared by both was absence of normal structures in the region of the inferior cerebellar vermis. Periodic alternating gaze appears to be associated with pathologic changes in the hindbrain in these and other reported cases.

Address correspondence and reprint requests to Dr. Thomas R. Hedges III, 750 Washington Street, Box 381, Boston, MA 02111

Received December 3, 1991. Accepted for publication in final form February 11, 1992.






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