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Progressive parkinsonism associated with Rosenthal fibers

Senile-onset Alexander's disease?

Department of Clinical Neurosciences, Roger Williams Medical Center, Brown University, Providence, RI (Dr. Friedman)
Department of Pathology (Dr. Ambler), Rhode Island Hospital, Brown University, Providence, RI.

Rosenthal fibers are present in several neurologic disorders. Their occurrence in widespread subependymal, subpial, and perivascular locations is thought to be diagnostic of Alexander's disease, but they have also been reported in rare adult cases. Some of these patients were neurologically intact with severe systemic illnesses. In symptomatic cases, the neurologic disorder has simulated multiple sclerosis. We report an elderly woman with progressive parkinsonism, dementia, and hallucinations whose brain showed severe Rosenthal fiber proliferation.

Address correspondence and reprint requests to Dr. Joseph H. Friedman, Roger Williams Medical Center, 50 Maude Street, Providence, RI 02908.

Received November 1, 1991. Accepted for publication in final form February 3, 1992.

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