| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Minneapolis, MN (Drs. Mortimer, Ebbitt, and Jun);
Department of Neurology, University of Minnesota Medical School, Minneapolis, MN (Dr. Mortimer)
Division of Health Services Research and Policy, School of Public Health, University of Minnesota, Minneapolis, MN (Dr. Finch).
We followed 65 patients with probable Alzheimer's disease, who were initially mildly to moderately impaired, with semiannual assessments of cognitive and functional performance for up to 4 years. Scores on the Mini Mental State Examination and a combination of instrumental and self-maintenance scales of activities of daily living were regressed on time of examination (measured in 6-month increments) to estimate cognitive and functional progression rates in individual patients. Lower scores on the verbal neuropsychological tests at the time of study entry, more aggressive behavior, and sleep disturbance during the first year of observation predicted faster cognitive progression. Faster functional progression was predicted by paranoid behavior, hallucinations, and activity disturbances during the first year and the presence of extrapyramidal signs and lower scores on nonverbal neuropsychological tests at the time of entry into the study. Hallucinations occurred independently of cognitive severity and may identify a distinct subgroup of patients with rapid functional progression. Because of the greater significance of functional progression for caregivers' ability to manage patients, the presence of specific behavior problems early in the disease course may help to identify individuals who will experience greater functional decline and be at risk for earlier institutionalization.
Supported by the NIA grant 1-P01-AG06309 and the Department of Veterans Affairs.
Received November 14, 1991. Accepted for publication in final form February 11, 1992.
Address correspondence and reprint requests to Dr. James A. Mortimer, GRECC(11G), VA Medical Center, Minneapolis, MN 55417.
This article has been cited by other articles:
|
|
 |
|
  S. Tangwongchai, N. Thavichachart, V. Senanarong, N. Poungvarin, K. Phanthumchinda, R. Praditsuwan, S. Nidhinandana, and S. Chankrachang Galantamine for the Treatment of BPSD in Thai Patients With Possible Alzheimer's Disease With or Without Cerebrovascular Disease American Journal of Alzheimer's Disease and Other Dementias, January 1, 2009; 23(6): 593 - 601. [Abstract] [PDF]
|
|
|
|
 |
|
 V. Raymont, A. Greathouse, K. Reding, R. Lipsky, A. Salazar, and J. Grafman Demographic, structural and genetic predictors of late cognitive decline after penetrating head injury Brain, February 1, 2008; 131(2): 543 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Scarmeas, J. Brandt, D. Blacker, M. Albert, G. Hadjigeorgiou, B. Dubois, D. Devanand, L. Honig, and Y. Stern Disruptive Behavior as a Predictor in Alzheimer Disease Arch Neurol, December 1, 2007; 64(12): 1755 - 1761. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Mioshi, C. M. Kipps, K. Dawson, J. Mitchell, A. Graham, and J. R. Hodges Activities of daily living in frontotemporal dementia and Alzheimer disease Neurology, June 12, 2007; 68(24): 2077 - 2084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Steffens, M. Maytan, M. J. Helms, and B. L. Plassman Prevalence and clinical correlates of neuropsychiatric symptoms in dementia American Journal of Alzheimer's Disease and Other Dementias, November 1, 2005; 20(6): 367 - 373. [Abstract] [PDF]
|
|
|
|
|
|
N. Scarmeas, J. Brandt, M. Albert, G. Hadjigeorgiou, A. Papadimitriou, B. Dubois, M. Sarazin, D. Devanand, L. Honig, K. Marder, et al. Delusions and Hallucinations Are Associated With Worse Outcome in Alzheimer Disease Arch Neurol, October 1, 2005; 62(10): 1601 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Scarmeas, M. Albert, J. Brandt, D. Blacker, G. Hadjigeorgiou, A. Papadimitriou, B. Dubois, M. Sarazin, D. Wegesin, K. Marder, et al. Motor signs predict poor outcomes in Alzheimer disease Neurology, May 24, 2005; 64(10): 1696 - 1703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Blasi, D. Brubacher, A. E. Zehnder, A. U. Monsch, M. Berres, and R. Spiegel Assessment of everyday behavior in Alzheimer's disease patients: Its significance for diagnostics and prediction of disease progression American Journal of Alzheimer's Disease and Other Dementias, May 1, 2005; 20(3): 151 - 158. [Abstract] [PDF]
|
|
|
|
|
|
M. Sarazin, Y. Stern, C. Berr, A. Riba, M. Albert, J. Brandt, and B. Dubois Neuropsychological predictors of dependency in patients with Alzheimer disease Neurology, March 22, 2005; 64(6): 1027 - 1031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Wilson, Y. Li, N. T. Aggarwal, L. L. Barnes, J. J. McCann, D. W. Gilley, and D. A. Evans Education and the course of cognitive decline in Alzheimer disease Neurology, October 12, 2004; 63(7): 1198 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Kang, S. H. Choi, B. H. Lee, Y. Jeong, D. S. Hahm, I. W. Han, J. L. Cummings, and D. L. Na Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI) J Geriatr Psychiatry Neurol, March 1, 2004; 17(1): 32 - 35. [Abstract] [PDF]
|
|
|
|
|
|
M. P. Caligiuri, G. Peavy, D. P. Salmon, D. R. Galasko, and L. J. Thal Neuromotor abnormalities and risk for psychosis in Alzheimer's disease Neurology, October 14, 2003; 61(7): 954 - 958. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Volicer and A. C. Hurley Review Article: Management of Behavioral Symptoms in Progressive Degenerative Dementias J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2003; 58(9): M837 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Religa, H. Laudon, M. Styczynska, B. Winblad, J. Naslund, and V. Haroutunian Amyloid {beta} Pathology in Alzheimer's Disease and Schizophrenia Am J Psychiatry, May 1, 2003; 160(5): 867 - 872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Sweet, M. I. Kamboh, S. R. Wisniewski, O. L. Lopez, W. E. Klunk, D. I. Kaufer, and S. T. DeKosky Apolipoprotein E and Alpha-1-Antichymotrypsin Genotypes Do Not Predict Time to Psychosis in Alzheimer's Disease J Geriatr Psychiatry Neurol, April 1, 2002; 15(1): 24 - 30. [Abstract] [PDF]
|
|
|
|
|
|
R. A. Sweet, V. L. Nimgaonkar, B. Devlin, O. L. Lopez, and S. T. DeKosky Increased familial risk of the psychotic phenotype of Alzheimer disease Neurology, March 26, 2002; 58(6): 907 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Nyenhuis, P. B. Gorelick, S. Freels, and D. C. Garron Cognitive and functional decline in African Americans with VaD, AD, and stroke without dementia Neurology, January 8, 2002; 58(1): 56 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Neumann, S. S. Araki, A. Arcelus, A. Longo, G. Papadopoulos, K. S. Kosik, K. M. Kuntz, and A. Bhattacharjya Measuring Alzheimer's disease progression with transition probabilities: Estimates from CERAD Neurology, September 25, 2001; 57(6): 957 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mungas, B. R. Reed, W. G. Ellis, and W. J. Jagust The Effects of Age on Rate of Progression of Alzheimer Disease and Dementia With Associated Cerebrovascular Disease Arch Neurol, August 1, 2001; 58(8): 1243 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Farlow, A. Hake, J. Messina, R. Hartman, J. Veach, and R. Anand Response of Patients With Alzheimer Disease to Rivastigmine Treatment Is Predicted by the Rate of Disease Progression Arch Neurol, March 1, 2001; 58(3): 417 - 422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Wilson, D. A. Bennett, D. W. Gilley, L. A. Beckett, L. L. Barnes, and D. A. Evans Premorbid Reading Activity and Patterns of Cognitive Decline in Alzheimer Disease Arch Neurol, December 1, 2000; 57(12): 1718 - 1723. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Hebert, R. S. Wilson, D. W. Gilley, L. A. Beckett, P. A. Scherr, D. A. Bennett, and D. A. Evans Decline of Language Among Women and Men With Alzheimer's Disease J. Gerontol. B. Psychol. Sci. Soc. Sci., November 1, 2000; 55(6): 354P - 361. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. S Wilson, D. W Gilley, D. A Bennett, L. A Beckett, and D. A Evans Hallucinations, delusions, and cognitive decline in Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, August 1, 2000; 69(2): 172 - 177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Wilson, D. A. Bennett, D. W. Gilley, L. A. Beckett, J. A. Schneider, and D. A. Evans Progression of Parkinsonism and Loss of Cognitive Function in Alzheimer Disease Arch Neurol, June 1, 2000; 57(6): 855 - 860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Wilson, D. A. Bennett, D. W. Gilley, L. A. Beckett, J. A. Schneider, and D. A. Evans Progression of parkinsonian signs in Alzheimer's disease Neurology, March 28, 2000; 54(6): 1284 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Del Ser, V. Hachinski, H. Merskey, and D. G. Munoz An autopsy-verified study of the effect of education on degenerative dementia Brain, December 1, 1999; 122(12): 2309 - 2319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Campbell, R. Peveler, K. Stein, C. Packer, D. Fidan, A. Stevens, N. Payne, R. Akehurst, R. Milne, J. Gabbay, et al. DEC methods for appraising new drugs BMJ, October 9, 1999; 319(7215): 1005 - 1005. [Full Text]
|
|
|
|
|
|
O. L. Lopez, S. R. Wisniewski, J. T. Becker, F. Boller, and S. T. DeKosky Psychiatric Medication and Abnormal Behavior as Predictors of Progression in Probable Alzheimer Disease Arch Neurol, October 1, 1999; 56(10): 1266 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Wilson, L. A. Beckett, D. A. Bennett, M. S. Albert, and D. A. Evans Change in Cognitive Function in Older Persons From a Community Population: Relation to Age and Alzheimer Disease Arch Neurol, October 1, 1999; 56(10): 1274 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Rao and C. G. Lyketsos Delusions in Alzheimer's Disease: A Review J Neuropsychiatry Clin Neurosci, November 1, 1998; 10(4): 373 - 382. [Abstract] [Full Text]
|
|
|
|
|
|
S. T. Chen, D. L. Sultzer, C. H. Hinkin, M. E. Mahler, and J. L. Cummings Executive Dysfunction in Alzheimer's Disease: Association With Neuropsychiatric Symptoms and Functional Impairment J Neuropsychiatry Clin Neurosci, November 1, 1998; 10(4): 426 - 432. [Abstract] [Full Text]
|
|
|
|
|
|
P. D. Harvey, E. Howanitz, M. Parrella, L. White, M. Davidson, R. C. Mohs, J. Hoblyn, and K. L. Davis Symptoms, Cognitive Functioning, and Adaptive Skills in Geriatric Patients With Lifelong Schizophrenia: A Comparison Across Treatment Sites Am J Psychiatry, August 1, 1998; 155(8): 1080 - 1086. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. J. Ferman, R. J. Ivnik, and J. A. Lucas Boston Naming Test Discontinuation Rule: Rigorous versus Lenient Interpretations Assessment, March 1, 1998; 5(1): 13 - 18. [Abstract] [PDF]
|
|
|
|
|
|
S. Nordin, O. Almkvist, B. Berglund, and L.-O. Wahlund Olfactory Dysfunction for Pyridine and Dementia Progression in Alzheimer Disease Arch Neurol, August 1, 1997; 54(8): 993 - 998. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Stern, M.-X. Tang, M. S. Albert, J. Brandt, D. M. Jacobs, K. Bell, K. Marder, M. Sano, D. Devanand, S. M. Albert, et al. Predicting Time to Nursing Home Care and Death in Individuals With Alzheimer Disease JAMA, March 12, 1997; 277(10): 806 - 812. [Abstract] [PDF]
|
|
|
|
|
|
R. McShane, J. Keene, K. Gedling, C. Fairburn, R. Jacoby, and T. Hope Do neuroleptic drugs hasten cognitive decline in dementia? Prospective study with necropsy follow up BMJ, January 25, 1997; 314(7076): 266 - 266. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Stern, X. Liu, M. Albert, J. Brandt, D. M. Jacobs, C. Del Castillo-Castaneda, K. Marder, K. Bell, M. Sano, and F. Bylsma Modeling the Influence of Extrapyramidal Signs on the Progression of Alzheimer Disease Arch Neurol, November 1, 1996; 53(11): 1121 - 1126. [Abstract] [PDF]
|
|
|
|
 |
|
 J. S. Meyer, K. Muramatsu, K. F. Mortel, K. Obara, and T. Shirai Prospective CT Confirms Differences Between Vascular and Alzheimer's Dementia Stroke, May 1, 1995; 26(5): 735 - 742. [Abstract] [Full Text]
|
|
|
|
|
|
N. Wolfe, B. R. Reed, J. L. Eberling, and W. J. Jagust Temporal Lobe Perfusion on Single Photon Emission Computed Tomography Predicts the Rate of Cognitive Decline in Alzheimer's Disease Arch Neurol, March 1, 1995; 52(3): 257 - 262. [Abstract] [PDF]
|
|
|
|
|
|
H. C. Chui, S. A. Lyness, E. Sobel, and L. S. Schneider Extrapyramidal Signs and Psychiatric Symptoms Predict Faster Cognitive Decline in Alzheimer's Disease Arch Neurol, July 1, 1994; 51(7): 676 - 681. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
