Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Arriagada, P. V.
Right arrow Articles by Hyman, B. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arriagada, P. V.
Right arrow Articles by Hyman, B. T.
NEUROLOGY 1992;42:1681
© 1992 American Academy of Neurology

Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease

Paulina V. Arriagada, MD, K. Marzloff, BA and Bradley T. Hyman, MD, PhD

Departments of Neuropathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (Dr. Arriagada)
Departments of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (K. Marzloff and Dr. Hyman).

We studied the topographic distribution of Alzheimer's disease (AD)-type pathologic changes in the brains of 25 presumed nondemented elderly individuals. Neurofibrillary tangles (NFT) and senile plaques (SP) were evaluated quantitatively in nine to 20 cytoarchitectural fields using thioflavine S, Alz-50, and anti-ß/A4 amyloid immunohistochemistry. Our observations suggest that (1) most individuals over the age of 55 have at least a few NFT and SP; (2) the topographic distribution of NFT and SP in nondemented elderly individuals follows a consistent pattern of vulnerability in different cytoarchitectural areas; (3) NFT occur most frequently in the entorhinal and perirhinal cortices and the CA1/subiculum field of the hippocampus, while neocortical areas are less frequently affected; (4) immunohistochemically defined subtypes of SP have distinct patterns of distribution. ß/A4 immunoreactive SP are present in neocortical areas > limbic areas. Alz-50 immunoreactive SP are infrequent and limited to those areas that contain Alz-50-positive neurons and NFT. These patterns closely match the hierarchical topographic distribution of NFT and SP observed in AD, suggesting a commonality in the pathologic processes that lead to NFT and SP in both aging and AD.

Address correspondence and reprint requests to Dr. Bradley T. Hyman, Department of Neurology, Massachusetts General Hospital, 32 Fruit Street, Boston, MA 02114.

Received December 4, 1991. Accepted for publication in final form February 14, 1992.

Supported by NIH grant AG08487, and the Brookdale Foundation. Dr. Arriagada is a fellow of the Educational Commission for Foreign Medical Graduates (ECFMG).




This article has been cited by other articles:


Home page
 JCBHome page
E. Inoue, M. Deguchi-Tawarada, A. Togawa, C. Matsui, K. Arita, S. Katahira-Tayama, T. Sato, E. Yamauchi, Y. Oda, and Y. Takai
Synaptic activity prompts {gamma}-secretase-mediated cleavage of EphA4 and dendritic spine formation
J. Cell Biol., May 4, 2009; 185(3): 551 - 564.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
B. C. Dickerson, A. Bakkour, D. H. Salat, E. Feczko, J. Pacheco, D. N. Greve, F. Grodstein, C. I. Wright, D. Blacker, H. D. Rosas, et al.
The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals
Cereb Cortex, March 1, 2009; 19(3): 497 - 510.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
L. De Beaumont, H. Theoret, D. Mongeon, J. Messier, S. Leclerc, S. Tremblay, D. Ellemberg, and M. Lassonde
Brain function decline in healthy retired athletes who sustained their last sports concussion in early adulthood
Brain, March 1, 2009; 132(3): 695 - 708.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A.M. Fjell, K.B. Walhovd, I. Amlien, A. Bjornerud, I. Reinvang, L. Gjerstad, T. Cappelen, F. Willoch, P. Due-Tonnessen, R. Grambaite, et al.
Morphometric Changes in the Episodic Memory Network and Tau Pathologic Features Correlate with Memory Performance in Patients with Mild Cognitive Impairment
AJNR Am. J. Neuroradiol., June 1, 2008; 29(6): 1183 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. W. Scheff, D. A. Price, F. A. Schmitt, S. T. DeKosky, and E. J. Mufson
Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
Neurology, May 1, 2007; 68(18): 1501 - 1508.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Oddo, V. Vasilevko, A. Caccamo, M. Kitazawa, D. H. Cribbs, and F. M. LaFerla
Reduction of Soluble Abeta and Tau, but Not Soluble Abeta Alone, Ameliorates Cognitive Decline in Transgenic Mice with Plaques and Tangles
J. Biol. Chem., December 22, 2006; 281(51): 39413 - 39423.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
E. Capetillo-Zarate, M. Staufenbiel, D. Abramowski, C. Haass, A. Escher, C. Stadelmann, H. Yamaguchi, O. D. Wiestler, and D. R. Thal
Selective vulnerability of different types of commissural neurons for amyloid {beta}-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology
Brain, November 1, 2006; 129(11): 2992 - 3005.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
D. R. Thal, E. Capetillo-Zarate, K. Del Tredici, and H. Braak
The Development of Amyloid beta Protein Deposits in the Aged Brain
Sci. Aging Knowl. Environ., March 8, 2006; 2006(6): re1 - re1.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
D. R. Thal, K. Del Tredici, and H. Braak
Neurodegeneration in Normal Brain Aging and Disease
Sci. Aging Knowl. Environ., June 9, 2004; 2004(23): pe26 - pe26.
[Abstract] [Full Text]

Home page
 NeurologyHome page
P. Giannakopoulos, F. R. Herrmann, T. Bussiere, C. Bouras, E. Kovari, D. P. Perl, J. H. Morrison, G. Gold, and P. R. Hof
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
Neurology, May 13, 2003; 60(9): 1495 - 1500.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
A. L. Guillozet, S. Weintraub, D. C. Mash, and M. M. Mesulam
Neurofibrillary Tangles, Amyloid, and Memory in Aging and Mild Cognitive Impairment
Arch Neurol, May 1, 2003; 60(5): 729 - 736.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
D. R. Thal, U. Rub, M. Orantes, and H. Braak
Phases of A{beta}-deposition in the human brain and its relevance for the development of AD
Neurology, June 25, 2002; 58(12): 1791 - 1800.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
M D Greicius, M D Geschwind, and B L Miller
Presenile dementia syndromes: an update on taxonomy and diagnosis
J. Neurol. Neurosurg. Psychiatry, June 1, 2002; 72(6): 691 - 700.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
T. Ohnishi, H. Matsuda, T. Tabira, T. Asada, and M. Uno
Changes in Brain Morphology in Alzheimer Disease and Normal Aging: Is Alzheimer Disease an Exaggerated Aging Process?
AJNR Am. J. Neuroradiol., October 1, 2001; 22(9): 1680 - 1685.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J. L. Price, A. I. Ko, M. J. Wade, S. K. Tsou, D. W. McKeel, and J. C. Morris
Neuron Number in the Entorhinal Cortex and CA1 in Preclinical Alzheimer Disease
Arch Neurol, September 1, 2001; 58(9): 1395 - 1402.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. J. de Leon, A. Convit, O. T. Wolf, C. Y. Tarshish, S. DeSanti, H. Rusinek, W. Tsui, E. Kandil, A. J. Scherer, A. Roche, et al.
Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-D-glucose/positron-emission tomography (FDG/PET)
PNAS, August 23, 2001; (2001) 191044198.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H. Petrovitch, L.R. White, G.W. Ross, S.C. Steinhorn, C.Y. Li, K.H. Masaki, D.G. Davis, J. Nelson, J. Hardman, J.D. Curb, et al.
Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based study
Neurology, July 24, 2001; 57(2): 226 - 234.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. M. Muir and D. K. Bilkey
Instability in the Place Field Location of Hippocampal Place Cells after Lesions Centered on the Perirhinal Cortex
J. Neurosci., June 1, 2001; 21(11): 4016 - 4025.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
T. W. Mitchell, J. Nissanov, L.-Y. Han, E. J. Mufson, J. A. Schneider, E. J. Cochran, D. A. Bennett, V. M.-Y. Lee, J. Q. Trojanowski, and S. E. Arnold
Novel Method to Quantify Neuropil Threads in Brains from Elders With or Without Cognitive Impairment
J. Histochem. Cytochem., December 1, 2000; 48(12): 1627 - 1638.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
M. Morishima-Kawashima, N. Oshima, H. Ogata, H. Yamaguchi, M. Yoshimura, S. Sugihara, and Y. Ihara
Effect of Apolipoprotein E Allele {{epsilon}}4 on the Initial Phase of Amyloid {beta}-Protein Accumulation in the Human Brain
Am. J. Pathol., December 1, 2000; 157(6): 2093 - 2099.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
F. A. Schmitt, D. G. Davis, D. R. Wekstein, C. D. Smith, J. W. Ashford, and W. R. Markesbery
""Preclinical"" AD revisited: Neuropathology of cognitively normal older adults
Neurology, August 8, 2000; 55(3): 370 - 376.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
P. A. Engel and M. Grunnet
Atypical Dementia and Spastic Paraplegia in a Patient with Primary Lateral Sclerosis and Numerous Neocortical Beta Amyloid Plaques: New Disorder or Alzheimer's Disease Variant?
J Geriatr Psychiatry Neurol, July 1, 2000; 13(2): 60 - 64.
[Abstract] [PDF]

Home page
 CMAJHome page
D. G. Munoz and H. Feldman
Causes of Alzheimer's disease
Can. Med. Assoc. J., January 1, 2000; 162(1): 65 - 72.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L.-F. Lue, Y.-M. Kuo, A. E. Roher, L. Brachova, Y. Shen, L. Sue, T. Beach, J. H. Kurth, R. E. Rydel, and J. Rogers
Soluble Amyloid {beta} Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
Am. J. Pathol., September 1, 1999; 155(3): 853 - 862.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. Funato, M. Enya, M. Yoshimura, M. Morishima-Kawashima, and Y. Ihara
Presence of Sodium Dodecyl Sulfate-Stable Amyloid {beta}-Protein Dimers in the Hippocampus CA1 Not Exhibiting Neurofibrillary Tangle Formation
Am. J. Pathol., July 1, 1999; 155(1): 23 - 28.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
G. B. Frisoni, M. P. Laakso, A. Beltramello, C. Geroldi, A. Bianchetti, H. Soininen, and M. Trabucchi
Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer's disease
Neurology, January 1, 1999; 52(1): 91 - 91.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
B. T. Hyman
New Neuropathological Criteria for Alzheimer Disease
Arch Neurol, September 1, 1998; 55(9): 1174 - 1176.
[Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
M. Yasuda, E. Mori, H. Kitagaki, H. Yamashita, N. Hirono, K. Shimada, K. Maeda, and C. Tanaka
Apolipoprotein E {epsilon}4 Allele and Whole Brain Atrophy in Late-Onset Alzheimer's Disease
Am J Psychiatry, June 1, 1998; 155(6): 779 - 784.
[Abstract] [Full Text]

Home page
 Arch NeurolHome page
P. Giannakopoulos, M. Duc, G. Gold, P. R. Hof, J.-P. Michel, and C. Bouras
Pathologic Correlates of Apraxia in Alzheimer Disease
Arch Neurol, May 1, 1998; 55(5): 689 - 695.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Yoshida, A. Watanabe, and Y. Ihara
Collapsin Response Mediator Protein-2 Is Associated with Neurofibrillary Tangles in Alzheimer's Disease
J. Biol. Chem., April 17, 1998; 273(16): 9761 - 9768.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. H. Morrison and P. R. Hof
Life and Death of Neurons in the Aging Brain
Science, October 17, 1997; 278(5337): 412 - 419.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
T. Gomez-Isla, J. L. Price, D. W. McKeel Jr., J. C. Morris, J. H. Growdon, and B. T. Hyman
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer''s Disease
J. Neurosci., July 15, 1996; 16(14): 4491 - 4500.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
P. Giannakopoulos, P. R. Hof, A.-S. Giannakopoulos, F. R. Herrmann, J.-P. Michel, and C. Bouras
Regional Distribution of Neurofibrillary Tangles and Senile Plaques in the Cerebral Cortex of Very Old Patients
Arch Neurol, December 1, 1995; 52(12): 1150 - 1159.
[Abstract] [PDF]

Home page
 NeuroscientistHome page
W. J. Strittmatter and A. D. Roses
Apolipoprotein E: Emerging Story in the Pathogenesis of Alzheimer's Disease
Neuroscientist, September 1, 1995; 1(5): 298 - 306.
[Abstract] [PDF]

Home page
 JAMAHome page
R. C. Petersen, G. E. Smith, R. J. Ivnik, E. G. Tangalos, D. J. Schaid, S. N. Thibodeau, E. Kokmen, S. C. Waring, and L. T. Kurland
Apolipoprotein E Status as a Predictor of the Development of Alzheimer's Disease in Memory-Impaired Individuals
JAMA, April 26, 1995; 273(16): 1274 - 1278.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
B. T. Hyman, H. L. West, G. W. Rebeck, F. Lai, and D. M. A. Mann
Neuropathological Changes in Down's Syndrome Hippocampal Formation: Effect of Age and Apolipoprotein E Genotype
Arch Neurol, April 1, 1995; 52(4): 373 - 378.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
P. R. Hof, C. Bouras, D. P. Perl, D. L. Sparks, N. Mehta, and J. H. Morrison
Age-Related Distribution of Neuropathologic Changes in the Cerebral Cortex of Patients With Down's Syndrome: Quantitative Regional Analysis and Comparison With Alzheimer's Disease
Arch Neurol, April 1, 1995; 52(4): 379 - 391.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
J. A. Golden, G. P. Nielsen, B. R. Pober, and B. T. Hyman
The Neuropathology of Williams Syndrome: Report of a 35-Year-Old Man With Presenile {beta}/A4 Amyloid Plaques and Neurofibrillary Tangles
Arch Neurol, February 1, 1995; 52(2): 209 - 212.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
L. M. Bierer, P. R. Hof, D. P. Purohit, L. Carlin, J. Schmeidler, K. L. Davis, and D. P. Perl
Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease
Arch Neurol, January 1, 1995; 52(1): 81 - 88.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. J. de Leon, A. Convit, O. T. Wolf, C. Y. Tarshish, S. DeSanti, H. Rusinek, W. Tsui, E. Kandil, A. J. Scherer, A. Roche, et al.
Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-D-glucose/positron-emission tomography (FDG/PET)
PNAS, September 11, 2001; 98(19): 10966 - 10971.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by AAN Enterprises, Inc.