| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
University School of Medicine, Atlanta, GA (Dr. Davis)
Duke University Medical Center, Durham, NC (Drs. Gray, Wilkinson, and Heyman)
Harvard Medical School, Boston, MA (Dr. Albert)
University of Washington, Seattle, WA (J. Hughes)
Washington University School of Medicine, St. Louis, MO (Drs. Gado and Kido)
Johns Hopkins University, Baltimore, MD (Dr. Kumar)
LA County/USC Medical Center, Los Angeles, CA (Dr. Destian)
AB Chandler Medical Center, Lexington, KY (Dr. Lee)
University of Alabama Hospital, Birmingham, AL (Dr. Duvall)
Veterans Administration Medical Center (Minneapolis), Minneapolis, MN (Dr. Nelson)
Montefiore Medical Center, Bronx, NY (Dr. Bello)
Veterans Administration Medical Center (Houston), Houston, TX (Dr. Weathers)
Brigham and Women's Hospital, Boston, MA (Drs. Jolesz and Kikinis)
Graduate Hospital, Philadelphia, PA (Dr. Brooks).
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) has developed procedures for standardized imaging and reporting of magnetic resonance (MR) findings in Alzheimer's disease (AD) for use by neuroradiologists in multiple medical centers using a variety of MR equipment and field strengths. After initial pretesting, we revised the protocol, expanded the summary rating scale to seven points, and added more illustrations. Fourteen participating neuroradiologists evaluated 28 MR scans of elderly patients, giving us the basis for judging interrater agreement. We obtained acceptable intraclass correlations (>0.79) for rating the size of the lateral and third ventricles and the temporal horn. Less satisfactory intraclass correlations occurred when rating other areas, including (1) global atrophy of the brain (0.70); (2) dilatation of the sulci of the temporal lobe (0.66); (3) frequency, location, and severity of white matter lesions (0.77); (4) sylvian fissure enlargement (0.70); and (5) cerebral sulcal dilatation (0.64). We also saw considerable variation in the reporting of cortical and lacunar infarcts. Despite careful design of the rating methodology and readings by experienced neuroradiologists, we did not find satisfactory interrater agreement for interpreting MR findings in elderly subjects. These findings may explain the difficulties encountered in applying similar subjective rating techniques that meet with success at one institution to multicenter studies. More objective and reproducible procedures are needed for interpretation of neuroimaging findings of AD in multicenter studies.
Supported by NIA grant AG06790.
Presented in part at the 43rd annual meeting of the American Academy of Neurology, Boston, MA, April 1991.
Received October 25, 1991. Accepted for publication in final form February 13, 1992.
Address correspondence and reprint requests to Dr. P.C. Davis, Department of Radiology/MRI, Egleston Children's Hospital, Emory University, 1405 Clifton Road, NE, Atlanta, GA 30322. Requests for information about CERAD and its copyrighted assessment batteries should be directed to Albert Heyman, MD, Duke University Medical Center, Box 3203, Durham, NC 27710.
This article has been cited by other articles:
|
|
 |
|
  P. M. Meyer, K. Strecker, K. Kendziorra, G. Becker, S. Hesse, D. Woelpl, A. Hensel, M. Patt, D. Sorger, F. Wegner, et al. Reduced {alpha}4{beta}2*-Nicotinic Acetylcholine Receptor Binding and Its Relationship to Mild Cognitive and Depressive Symptoms in Parkinson Disease Arch Gen Psychiatry, August 1, 2009; 66(8): 866 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Hilker, A. V. Thomas, J. C. Klein, S. Weisenbach, E. Kalbe, L. Burghaus, A. H. Jacobs, K. Herholz, and W. D. Heiss Dementia in Parkinson disease: Functional imaging of cholinergic and dopaminergic pathways Neurology, December 13, 2005; 65(11): 1716 - 1722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Jack Jr., D. W. Dickson, J. E. Parisi, Y. C. Xu, R. H. Cha, P. C. O'Brien, S. D. Edland, G. E. Smith, B. F. Boeve, E. G. Tangalos, et al. Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia Neurology, March 12, 2002; 58(5): 750 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Lee, K. U. Lee, D. Y. Lee, K. W. Kim, J. H. Jhoo, J. H. Kim, K. H. Lee, S. Y. Kim, S. H. Han, and J. I. Woo Development of the Korean Version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K): Clinical and Neuropsychological Assessment Batteries J. Gerontol. B. Psychol. Sci. Soc. Sci., January 1, 2002; 57(1): P47 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P J de Vries, W G Honer, P M Kemp, and P J McKenna Dementia as a complication of schizophrenia J. Neurol. Neurosurg. Psychiatry, May 1, 2001; 70(5): 588 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Bryan, J. Cai, G. Burke, R. G. Hutchinson, D. Liao, J. F. Toole, A. P. Dagher, and L. Cooper Prevalence and Anatomic Characteristics of Infarct-like Lesions on MR Images of Middle-Aged Adults: The Atherosclerosis Risk in Communities Study AJNR Am. J. Neuroradiol., August 1, 1999; 20(7): 1273 - 1280. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. W. Small, J. C. Mazziotta, M. T. Collins, L. R. Baxter, M. E. Phelps, M. A. Mandelkern, A. Kaplan, A. La Rue, C. F. Adamson, L. Chang, et al. Apolipoprotein E Type 4 Allele and Cerebral Glucose Metabolism in Relatives at Risk for Familial Alzheimer Disease JAMA, March 22, 1995; 273(12): 942 - 947. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Marder, M. Richards, J. Bello, K. Bell, M. Sano, L. Miller, M. Folstein, M. Albert, and Y. Stern Clinical Correlates of Alzheimer's Disease With and Without Silent Radiographic Abnormalities Arch Neurol, February 1, 1995; 52(2): 146 - 151. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
