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Incidence of migraine headache

A population-based study in Olmsted County, Minnesota

Departments of Health Sciences Research, Mayo Clinic and Foundation, Rochester, MN (Drs. Stang, O'Fallon, Guess, and Melton, and C.M. Beard)
Departments of Neurology, Mayo Clinic and Foundation, Rochester, MN (Drs. Yanagihara and Swanson)
Department of Epidemiology, University of North Carolina at Chapel Hill School of Public Health, Chapel Hill, NC (Drs. Stang and Guess)
Glaxo Inc. Research Institute, Research Triangle Park, NC (Dr. Stang).

To determine the incidence of clinically detected migraine headache in the defined population of Olmsted County, MN, 1979-1981, we screened over 6,400 patient records from several diagnostic rubrics using the unique resources of the Rochester Epidemiology Project for population-based studies. We identified 629 Olmsted County residents who fulfilled the International Headache Society's 1988 criteria for newly diagnosed migraine headache between 1979 and 1981. The overall age-adjusted incidence was 137 per 100,000 person-years for males and 294 per 100,000 person-years for females. The highest incidence in females was among those aged 20 to 24 years (689 per 100,000 person-years), and in males, the highest incidence was among those aged 10 to 14 years (246 per 100,000 person-years). From 1979 to 1981, there was a striking increase in the age-adjusted incidence in those under 45 years of age: the incidence increased 34% in women and 100% for men. This is the first population-based study of migraine incidence across all ages.

Supported in part by the Rochester Epidemiology Project (AR30582) and the Neuroepidemiology Program Project (NS17750) from the National Institutes of Health, and by a research grant from Glaxo Inc. Research Institute.

Presented in part at the 44th annual meeting of the American Academy of Neurology, San Diego, CA, May 1992.

Received November 14, 1991. Accepted for publication in final form February 6, 1992.

Address correspondence and reprint requests to Dr. Paul E. Stang, Applied Healthcare Research, Glaxo Inc. Research Institute, 5 Moore Drive, CS 1130, Research Triangle Park, NC 27709.

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