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Epitope analysis of senile plaque components in the hippocampus of patients with Parkinson's disease

Departments of Pathology and Laboratory Medicine (Division of Anatomic Pathology) (Drs. Arai, Schmidt, Lee, and Trojanowski) and Neurology (Dr. Hurtig), The University of Pennsylvania School of Medicine, and the Department of Neurology (Drs. Hurtig and Adler), The Graduate Hospital, Philadelphia, PA; and the Upjohn Company (Dr. Greenberg), Kalamazoo. MI.

We conducted an epitope analysis of senile plaque (SP) proteins on hippocampal SPs in patients with Parkinson's disease (PD), using a library of antibodies to proteins implicated in the genesis of hippocampal SPs in Alzheimer's disease (AD). The library included antibodies to the ß-amyloid protein (ß-AP), domains outside the ß-AP in ß-amyloid precursor proteins (ß-APPs), ubiquitin, diverse neuronal cytoskeletal proteins, and polypeptides located mainly in axon terminals. We obtained samples of hippocampus at autopsy from 14 PD patients, 10 of whom were demented. As in the AD hippocampus, the SPs detected by conventional stains in five of the 10 demented subjects contained the ß-AP and flanking domains in ß-APPs as well as epitopes in T, neurofilament proteins, and synaptophysin. Further, with the exception of the ß-AP, epitopes in the other proteins were confined to the coronas of SPs, while clathrin light chain, microtubule-associated protein 5, and neural cell adhesion molecules were almost undetectable or absent in the neuropil occupied by SPs. The same group of antibodies rarely labeled SPs in the other five demented PD subjects or in the four nondemented PD subjects, and conventional stains for amyloid and neurofibrillary pathology revealed rare SPs in these cases. Hence, when conventional stains reveal lesions diagnostic of AD in PD patients, the molecular features of the hippocampal SPs in these patients are the same as those in SPs of the AD hippocampus.

Address correspondence and reprint requests to Dr. J.Q. Trojanowski, Department of Pathology and Laboratory Medicine, The University of Pennsylvania School of Medicine, HUP/Maloney Basement A009, Philadelphia. PA 19104.

Supported in part by AG-09215 and AG-10124.

Received November 6, 1991. Accepted for publication in final form December 27. 1991.

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