| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of Neurology (Drs. Ravnborg and Soelberg Sørensen) and Clinical Neurophysiology (Dr. Liguori), Rigshospitalet, and the Department of Magnetic Resonance (Drs. Christiansen and Larsson), Hvidovre Hospital, Copenhagen, Denmark.
In a prospective study, we evaluated the technique of magnetically evoked motor potentials (MEP) in the diagnosis of multiple sclerosis (MS). We consecutively included 68 patients with symptoms or signs compatible with a demyelinative CNS affection. We subjected all patients to CSF analysis, MRI studies of the brain and brainstem, visual evoked potentials (VEP), brainstem auditory evoked potentials (BAEP), and somatosensory evoked potentials (SSEP). We then used the results to categorize the patients according to the Poser criteria of multiple sclerosis. Blinded from the results of the above investigations, one of the authors made MEP recordings from three muscles in the upper limbs and two in the lower limbs in all 68 patients. Forty patients received an MS diagnosis, and in these, MRI was positive in 88%, MEP in 83%, VEP in 67%, SSEP in 63%, and BAEP in 42%. As to the diagnosis of MS, the reliability of a prolonged central motor conduction time (CMCT) was 0.83 (0.73 to 0.93), while the reliability of a normal CMCT was 0.75 (0.61 to 0.98). The information gained by MRI was best supplemented by VEP. Of the neurophysiologic tests, the MEP was in closest agreement with the MRI with a concordance of 85%.
Address correspondence and reprint requests to Dr. Mads Ravnborg, Department of Neurology, N2081, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Supported by grants from the Danish Multiple Sclerosis Society, Fondsbørsvekselerer Henry Hansen og hustru, Carla Hansen, født Westergaards legat, Lykfeldts legat, and the Foundation for Experimental Research in Neurology.
Received September 6, 1991. Accepted for publication in final form December 12, 1991.
This article has been cited by other articles:
|
|
 |
|
  L. Feuillet, J. Pelletier, L. Suchet, A. Rico, A. Ali Cherif, J. Pouget, and S. Attarian Prospective clinical and electrophysiological follow-up on a multiple sclerosis population treated with interferon beta-1 a: a pilot study Multiple Sclerosis, April 1, 2007; 13(3): 348 - 356. [Abstract] [PDF]
|
|
|
|
 |
|
 S Brostrom, J L Frederiksen, P Jennum, and G Lose Motor evoked potentials from the pelvic floor in patients with multiple sclerosis J. Neurol. Neurosurg. Psychiatry, April 1, 2003; 74(4): 498 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Schmierer, K. Irlbacher, P. Grosse, S. Roricht, and B.-U. Meyer Correlates of disability in multiple sclerosis detected by transcranial magnetic stimulation Neurology, October 22, 2002; 59(8): 1218 - 1224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Provini, R. Vetrugno, S. Meletti, G. Plazzi, L. Solieri, E. Lugaresi, G. Coccagna, and a. P. Montagna Motor pattern of periodic limb movements during sleep Neurology, July 24, 2001; 57(2): 300 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Weber, A. Eisen, H. G. Stewart, and P. M. Andersen Preserved slow conducting corticomotoneuronal projections in amyotrophic lateral sclerosis with autosomal recessive D90A CuZn-superoxide dismutase mutation Brain, July 1, 2000; 123(7): 1505 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Schmierer, L. Niehaus, S. Röricht, and B.-U. Meyer Conduction deficits of callosal fibres in early multiple sclerosis J. Neurol. Neurosurg. Psychiatry, May 1, 2000; 68(5): 633 - 638. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
