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NEUROLOGY 1992;42:1246
© 1992 American Academy of Neurology

No evidence for reduced thrombocyte cytochrome oxidase activity in Alzheimer's disease

A. J. Van Zuylen, G. J.C.G.M. Bosman, PhD, W. Ruitenbeek, PhD, P.J.C. Van Kalmthout, MD and W. J. De Grip, PhD

Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands. (A.J. Van Zuylen and Drs. Bosman and De Grip)
Department of Pediatrics, University Hospital of Nijmegen, Nijmegen, The Netherlands. (Dr. Ruitenbeek)
Psychogeriatric Institution St. Joachim en Anna, Nijmegen, The Netherlands. (Dr. Van Kalmthout)

We measured cytochrome oxidase activity in thrombocytes from patients with senile dementia of the Alzheimer type. We found no decrease in enzyme activity in Alzheimer's disease patients when compared with patients with multi-infarct dementia, with young control donors, and with age-matched control donors.

Address correspondence and reprint requests to Dr. Giel Bosman, Department of Biochemistry, University of Nijmegen, P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands.

Supported by a grant from the JANIVO foundation. The research of Dr. G. Bosman has been made possible by a fellowship of the Royal Netherlands Academy of Arts and Sciences.

Received September 11, 1991. Accepted for publication in final form November 19, 1991.






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