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Neurolymphomatosis

A clinicopathologic syndrome re-emerges

Department of Neurology, Columbia-Presbyterian Medical Center, New York, NY. (Drs. Diaz-Arrastia, Younger, Fetell, Lovelace, and Rowland)
Department of Pathology, Columbia-Presbyterian Medical Center, New York, NY. (Drs. Hair, Inghirami, Hays, and Knowles)
Department of Ophthalmology, Columbia-Presbyterian Medical Center, New York, NY. (Dr. Odel)

We describe a patient with sensorimotor peripheral neuropathy and cranial neuropathy due to autopsy-proven neurolymphomatosis defined by infiltration of peripheral nerves by tumor cells and review the findings in 39 previously reported patients. The cause of the neuropathy is not known. The association with immune-deficient states suggests virally mediated pathogenesis, possibly a retrovirus.

Address correspondence and reprint requests to Dr. David S. Younger, Columbia-Presbyterian Medical Center, 710 West 168th Street, Box 53 New York, NY 10032-3784.

Supported by Center Grants from the Muscular Dystrophy Association, NIH (NINDS-NS11766), and the GCRC (RR-00645); and NIH (E406337 and CA40236 to Dr. Knowles).

Received April 4, 1991. Accepted for publication in final form November 5, 1991.

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