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Departments of Psychiatry (Neuropsychiatry) and Medicine (Neurology), Medical College of Pennsylvania, Allegheny Campus, Pittsburgh, PA (Dr. Coffey)
Department of Psychiatry, Duke University Medical Center, Durham, NC.(Drs. Parashos, Figiel, and Webb, and S.A.R. Soady and L.J. Patterson)
Department of Radiology, Duke University Medical Center, Durham, NC. (Drs. Spritzer and Djang)
Department of Community and Family Medicine, Duke University Medical Center, Durham, NC. (Dr. Sullivan)
Department of Biometry, Duke University Medical Center, Durham, NC. (Dr. Wilkinson)
Seventy-six healthy adults underwent magnetic resonance imaging (1.5 T) to investigate the effects of age on regional cerebral volumes and on the frequency and severity of cortical atrophy, lateral ventricular enlargement, and subcortical hyperintensity. Increasing age was associated with (1) decreasing volumes of the cerebral hemispheres (0.23% per year), the frontal lobes (0.55% per year), the temporal lobes (0.28% per year), and the amygdalahippocampal complex (0.30% per year); (2) increasing volumes of the third ventricle (2.8% per year) and the lateral ventricles (3.2% per year); and (3) increasing odds of cortical atrophy (8.9% per year), lateral ventricular enlargement (7.7% per year), and subcortical hyperintensity in the deep white matter (6.3% per year) and the pons (8.1% per year). Many elderly subjects did not exhibit cortical atrophy or lateral ventricular enlargement, however, indicating that such changes are not inevitable consequences of advancing age. These data should provide a useful clinical context within which to interpret changes in regional brain size associated with "abnormal" aging.
Address correspondence and reprint requests to Dr. C. Edward Coffey, Allegheny Neuropsychiatric Institute, 7777 Steubenville Pike, Oakdale, PA 15071.
Supported in part by grants MH-41803, MH-30723, and MH-40159 from the National Institute of Mental Health, Bethesda, MD; by grant RR-30 from the National Institutes of Health; and by the North Carolina United Way.
Presented in part at the 43rd annual meeting of the American Academy of Neurology, Boston, MA, April 1991.
Received June 28, 1991. Accepted for publication in final form August 22, 1991.
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