| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Multiple Sclerosis NMR Research Group (Drs. Plant, Kermode, Turano, Moseley, Miller, MacManus, Halliday, and McDonald), Institute of Neurology and The National Hospital for Neurology and Neurosurgery; and Moorfields Eye Hospital (Drs. Plant, Moseley, and McDonald), London, England.
We have studied 18 patients with relapsing-remitting multiple sclerosis (MS) who had symptomatic visual field defects due to retrochiasmal lesions. In 17, the lesion responsible was identified by magnetic resonance imaging (MRI), computed x-ray tomography (CT), or both. The lesion responsible involved the posterior optic radiations in eight cases, the optic tract and lateral geniculate nucleus in six, and the posterior limb of the internal capsule in three. The prognosis for recovery of the field defect was good; complete recovery occurred in 14 patients, and only two showed no recovery at all. The striking characteristic of the lesions was that most were unusually large; indeed, many were detectable on CT as well as MRI. Half-field asymmetries of either amplitude or latency of the visual evoked potentials (VEPs), consistent with a postchiasmal lesion, were present in only five out of 13 patients acutely. In only three of these did the abnormality persist at follow-up. We conclude that only large postchiasmal lesions are likely to cause symptomatic homonymous field defects in MS, usually characterized by rapid recovery. Hemifield VEPs have a low sensitivity for the detection of postchiasmal as compared with prechiasmal abnormalities.
Address correspondence and reprint requests to Dr. Gordon Plant, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, England.
Received January 15, 1991. Accepted for publication in final form June 10, 1991.
This article has been cited by other articles:
|
|
 |
|
  D. S. Reich, S. A. Smith, E. M. Gordon-Lipkin, A. Ozturk, B. S. Caffo, L. J. Balcer, and P. A. Calabresi Damage to the Optic Radiation in Multiple Sclerosis Is Associated With Retinal Injury and Visual Disability Arch Neurol, August 1, 2009; 66(8): 998 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Sisto, M. Trojano, M. Vetrugno, T. Trabucco, G. Iliceto, and C. Sborgia Subclinical Visual Involvement in Multiple Sclerosis: A Study by MRI, VEPs, Frequency-Doubling Perimetry, Standard Perimetry, and Contrast Sensitivity Invest. Ophthalmol. Vis. Sci., April 1, 2005; 46(4): 1264 - 1268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M A Tamhankar, C E Markowitz, and S L Galetta Checkerboard fields in multiple sclerosis J. Neurol. Neurosurg. Psychiatry, February 1, 2005; 76(2): 268 - 268. [Full Text] [PDF]
|
|
|
|
 |
|
 P. B. Pennell The importance of monotherapy in pregnancy Neurology, June 10, 2003; 60(90114): S31 - 38. [Abstract] [Full Text]
|
|
|
|
|
|
E. Kaaja, R. Kaaja, and V. Hiilesmaa Major malformations in offspring of women with epilepsy Neurology, February 25, 2003; 60(4): 575 - 579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Faro, F. B. Mohamed, J. I. Tracy, R. M. Elfont, A. B. Pinus, F. D. Lublin, R. A. Koenigsberg, C. Y. Chen, and F. Y. Tsai Quantitative Functional MR Imaging of the Visual Cortex at 1.5 T as a Function of Luminance Contrast in Healthy Volunteers and Patients with Multiple Sclerosis AJNR Am. J. Neuroradiol., January 1, 2002; 23(1): 59 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Caruana, M. B. Davies, S. J. M. Weatherby, R. Williams, N. Haq, D. H. Foster, and C. P. Hawkins Correlation of MRI lesions with visual psychophysical deficit in secondary progressive multiple sclerosis Brain, July 1, 2000; 123(7): 1471 - 1480. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
