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From the Department of Neurology (J. Vanneste, P. Augustijn), St. Lucasziekenhuis; the Department of Neurosurgery (C. Dirven), Academic Hospital, Free University of Amsterdam; the Department of Neurosurgery (W.F. Tan), Academic Medical Centre, University of Amsterdam; and the Department of Neurosurgery (Z.D. Goedhart), Municipal Hospital Slotervaart, Amsterdam, The Netherlands.
We performed a multicenter retrospective study in 166 consecutive patients shunted for presumed normal-pressure hydrocephalus (NPH) in the four neurosurgical departments of Amsterdam. Overall improvement occurred in 36%, substantial improvement in 21%. In the subgroup of idiopathic NPH (N = 127), marked improvement was only 15%. The incidence of shunt-responsive NPH in our area was 2.2/million/year. The rate of severe and moderate shunt-related complications was 28%, leading to death or severe residual morbidity in 7%. The substantial benefit/serious harm ratio in the whole group was only three (21%/7%), decreasing to 1.7 in idiopathic NPH. By excluding patients at high surgical risk, this ratio might have risen to 10 in the whole group and to six in idiopathic NPH. Our experience is much less favorable than that encountered in the literature, reporting overall improvement in 74% and marked improvement in 55% of the shunted patients. We conclude that NPH is probably a very rare and still overdiagnosed syndrome and that the overall morbidity rate for each patient demonstrating meaningful improvement is high.
Address correspondence and reprint requests to Dr. J. Vanneste, Department of Neurology, St. Lucasziekenhuis 164, 1061 AE Amsterdam, The Netherlands.
Received March 6, 1991. Accepted for publication in final form June 17, 1991
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