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Memory in a case of bilateral thalamic infarction

From the Brain Behavior Laboratory, Departments of Psychiatry (Drs. Malamut and Gur) and Radiology (Dr. Grossman), University of Pennsylvania, Philadelphia, PA; the Department of Neurology (Dr. Graff-Radford), Mayo Clinic Jacksonville, Jacksonville, FL; and the Department of Neurology (Dr. Chawluk), Good Samaritan Regional Medical Center, Pottsville, PA.

The role of individual structures within the diencephalon for memory functioning is unknown. We present anatomic localization of lesions and a longitudinal neuropsychological profile of a young man who had a bilateral diencephalic stroke in the interpeduncular profundus arterial territory. MRI localized the lesions to the mamillothalamic tracts and inferior thalamic peduncle. The amnesia was characterized by severe impairment in explicit recall of new facts and events, while word-completion priming and remote memory were intact. We suggest that the memory deficit results from a disconnection of the diencephalon from the medial temporal region.

Address correspondence and reprint requests to Dr. Barbara Malamut, Department of Psychology, Philadelphia Geriatric Center, 5301 Old York Rd., Philadelphia, PA 19141.

Supported in part by the Postdoctoral Fellowship from the MacArthur Foundation Research Network I (Psychobiology of Depression and Other Affective Disorders).

Presented in part at the 1989 Annual Meeting of the International Neuropsychological Society, Vancouver, BC, Canada

Received January 17, 1991. Accepted for publication in final form June 5, 1991.

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