HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Riggs, J. E. Articles by Jenkins, J. J. Search for Related Content PubMed PubMed Citation Articles by Riggs, J. E. Articles by Jenkins, J. J., III

Cardioskeletal mitochondria1 myopathy associated with chronic magnesium deficiency

From the Departments of Neurology, Pediatrics, Medicine, Pathology, and Community Medicine, West Virginia University School of Medicine, Morgantown, wv.

A 3-year-old boy presenting with convulsions and carpopedal spasm had hypomagnesemia and hypermagnesuria due to congenital magnesium-losing nephropathy. Despite chronic oral and intermittent intravenous magnesium supplementation, he remained chronically hypomagnesemic. At age 4, he developed a progressive proximal myopathy and dilated hypertrophic cardiomyopathy that ultimately contributed to his death at age 14 years. Skeletal and cardiac muscle specimens showed a mitochondria1 myopathy with increased numbers of enlarged, structurally abnormal mitochondria. Muscle magnesium content was markedly decreased. Chronic oral and intermittent intravenous magnesium supplementation may be inadequate to prevent the progressive cardioskeletal myopathy associated with the chronic magnesium deficiency of congenital magnesium-losing nephropathy.

Address correspondence and reprint requests to Dr. J.E. Riggs, Department of Neurology, West Virginia University Health Sciences Center, Morgantown, WV 26506.

Presented in part at the 35th annual meeting of the American Academy of Neurology, San Diego, CA, April 1983, and the Annual Meeting of the American Pediatric Society and the Society for Pediatric Research, 1983.

Received April 24, 1991. Accepted for publication in final form June 4, 1991.

This article has been cited by other articles:

				K. T. Weber, W. B. Weglicki, and R. U. Simpson Macro- and micronutrient dyshomeostasis in the adverse structural remodelling of myocardium Cardiovasc Res, February 15, 2009; 81(3): 500 - 508. [Abstract] [Full Text] [PDF]

				Antiepileptics, pregnancy and the child DTB, February 1, 2005; 43(2): 13 - 16. [Abstract] [Full Text] [PDF]

				N Adab, U Kini, J Vinten, J Ayres, G Baker, J Clayton-Smith, H Coyle, A Fryer, J Gorry, J Gregg, et al. The longer term outcome of children born to mothers with epilepsy J. Neurol. Neurosurg. Psychiatry, November 1, 2004; 75(11): 1575 - 1583. [Abstract] [Full Text] [PDF]

				W. O. Tatum IV, J. Liporace, S. R. Benbadis, and P. W. Kaplan Updates on the Treatment of Epilepsy in Women Arch Intern Med, January 26, 2004; 164(2): 137 - 145. [Abstract] [Full Text] [PDF]

				J. Liporace and A. D'Abreu Epilepsy and Women's Health: Family Planning, Bone Health, Menopause, and Menstrual-Related Seizures Mayo Clin. Proc., April 1, 2003; 78(4): 497 - 506. [Abstract] [PDF]

				N Adab, A Jacoby, D Smith, and D Chadwick Additional educational needs in children born to mothers with epilepsy J. Neurol. Neurosurg. Psychiatry, January 1, 2001; 70(1): 15 - 21. [Abstract] [Full Text] [PDF]

				H. R. Jones and S. M. de la Monte Case 22-1998- A 22-Year-Old Man with a Cardiac Transplant and Creatine Kinase Elevation N. Engl. J. Med., July 16, 1998; 339(3): 182 - 190. [Full Text] [PDF]