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NEUROLOGY 1990;40:813
© 1990 American Academy of Neurology

Flow quantification in the superior sagittal sinus using magnetic resonance

Heinrich Mattle, MD, Robert R. Edelman, MD, Moshe A. Reis, PhD and Dennis J. Atkinson, MS

Harvard Medical School and Department of Radiology, New England Deaconess Hospital (Dr. Mattle), and Department of Radiology, Beth Israel Hospital (Drs. Mattle, Edelman, and Reis, and Mr. Atkinson), Boston, MA; and Siemens Medical Systems (Mr. Atkinson), Iselin, NJ.

To date, the intracerebral veins and venous sinuses have not been amenable to noninvasive study. We describe a magnetic resonance (MR) technique using "bolus tracking" for rapid imaging and measurement of cerebral venous flow. We specifically applied the technique to the superior sagittal sinus, but it can be used for evaluation of other cerebral venous structures. In 10 healthy subjects and 21 patients referred for MR brain studies, mean flow was 420 ml/min. There was a significant inverse correlation between blood flow and age. There were dynamic changes in cerebral blood flow (CBF) during hyperventilation and hypercapnia. Since the cerebral cortex drains almost exclusively to the superior sagittal sinus, these flow measurements represent an index of global CBF. MR flow quantification provides a new means for assessing dynamic changes in CBF, and may prove useful for monitoring the effects of various disease processes and pharmaceutical agents on CBF.

Address correspondence and reprint requests to Dr. Robert R. Edelman, Director of Magnetic Resonance Imaging, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215.

Received September 7, 1989. Accepted for publication in final form October 5, 1989.

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