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CCK-8S inhibits l-dopa–induced dyskinesias in parkinsonian squirrel monkeys

From Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK.

Systemic administration of CCK-8S (1 or 10 µg/kg IP) markedly inhibited l-dopa-induced dyskinesias in parkinsonian monkeys, but did not interfere with locomotor stimulation by l-dopa. CCK analogues may be useful antidyskinetic agents for improved control of Parkinson's disease.

Address correspondence and reprint requests to Dr. S. Boyce, Merck Sharp & Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK.

Received August 15, 1989. Accepted for publication in final form September 12, 1989.

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