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NEUROLOGY 1990;40:632
© 1990 American Academy of Neurology

Cerebrospinal fluid levels of diazepam-binding inhibitor in neurodegenerative disorders with dementia

C. Ferrarese, MD, PhD, I. Appollonio, MD, M. Frigo, MD, S. Meregalli, MD, R. Piolti, MD, F. Tamma, MD and L. Frattola, MD

Neurological Clinic, University of Milan, S. Gerardo Hospital, Monza, Italy.

We investigated CSF levels of diazepam-binding inhibitor (DBI), a recently discovered neuropeptide that allosterically modulates GABAergic transmission, in various neurodegenerative disorders with dementia (28 patients with Parkinson's disease, 10 with Alzheimer's disease, 7 with Huntington's chorea). We applied a battery of neuropsychological tests to determine the degree of dementia and to exclude the presence of mood alterations. CSF DBI levels were elevated in parkinsonian subjects with dementia and in patients with Alzheimer's disease, but decreased in Huntington's chorea patients. We hypothesize that modifications of CSF DBI levels may be related to a functional or structural alteration of the GABAergic System.

Address correspondence and reprint requests to Dr. Carlo Ferrarese, Clinica Neurologica, via Donizetti, 106,20052 Monza (MI), Italy.

Received July 25, 1989. Accepted for publication in final form September 27, 1989.




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