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NEUROLOGY 1990;40:600
© 1990 American Academy of Neurology

Survival of patients with amyotrophic lateral sclerosis in 2 Danish counties

Peter Brøgger Christensen, MD, Else Højer-Pedersen, MD and Niels Bjørn Jensen, MD

Department of Neurology, Aalborg Hospital (Drs. Christensen and Højer-Pedersen), Aalborg, and Department of Neurology, Aarhus University Hospital (Dr. Jensen), Aarhus, Denmark.

We investigated the survival of patients with amyotrophic lateral sclerosis (ALS) in a follow-up study of all patients hospitalized with the disease in 2 Danish counties during the period 1974 to 1986. There were 186 patients, with a mean age at diagnosis of 64.3 years. The median survival time was 12 months from diagnosis, the 3-year survival rate was 12%, and the 5-year survival rate 4%. (The corresponding figures from onset were 23 months, 26%, and 7%.) Old age and bulbar findings at onset were negative prognostic factors. For each clinical category, the annual death rate remained constant throughout the observation period, indicating the effects of a steadily progressing degenerative disorder. We found no evidence of the existence of a separate variety of ALS, associated with long survival.

Address correspondence and reprint requests to Dr. Peter Brøgger Christensen, Department of Neurology, Aarhus University Hospital, Aarhus Kommunehospital, DK-8000 Aarhus C, Denmark.

Received January 13, 1989. Accepted for publication in final form September 14, 1989.




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