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Dextromethorphan for treatment Of complex partial seizures

Departments of Neurology (Drs. Fisher, Lesser, Hart, and Gordon, Ms. Cysyk and Ms. Schwerdt) and Neurosurgery (Drs. Fisher and Lesser), The Johns Hopkins University School of Medicine, and NOVA Pharmaceuticals (Drs. Pontecorvo and Ferkany), Baltimore, MD.

We performed a double-blind, crossover, add-on study of the antitussive agent dextromethorphan (DM 120 mg/d) as therapy for seizures on 9 patients suffering from severe complex partial seizures. DM had no significant influence on key laboratory values, nor on anticonvulsant drug levels. Side effects were negligible. Complex partial seizure frequency increased 25% during the DM arm of the study, although this increase was not clinically significant.

Address correspondence and reprint requests to Dr. Robert S. Fisher, The Johns Hopkins University School of Medicine, Meyer 1–130, 600 North Wolfe Street, Baltimore, MD 21205.

Supported by NOVA Pharmaceuticals, Baltimore, MD

Received June 19, 1989. Accepted for publication in final form August 10, 1989.