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Human immunodeficiency Virus wasting syndrome may represent a treatable myopathy

Departments of Neurology (Drs. Simpson, Bender, Farraye, and Mendelson), Pathology, Division of Neuropathology (Dr. Wolfe), and Clinical Neurophysiology (Drs. Simpson. Farraye, and Mendelson), Mount Sinai Medical Center, New York, NY.

We evaluated 5 patients with the diagnosis of HIV wasting syndrome. None had severe diarrhea or other causes for malabsorption. All had myopathy by clinical, laboratory, and muscle biopsy criteria. Withdrawal of azidothymidine in 3 patients did not lead to improvement. Corticosteroid therapy was effective in 3 patients.

Address correspondence and reprint requests to Dr. David M. Simpson, Department of Clinical Neurophysiology, Box 1052, Mount Sinai Hospital, New York, NY 10029.

Presented in part at the 41st annual meeting of the American Academy of Neurology, Chicago, IL, April 1989.

Received July 5, 1989. Accepted for publication in final form August 23, 1989.