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NEUROLOGY 1990;40:532
© 1990 American Academy of Neurology

White matter dementia in chronic toluene abuse

Christopher M. Filley, MD, Robert K. Heaton, PhD and Neil L. Rosenberg, MD

Departments of Neurology (Drs. Filley and Rosenberg) and Psychiatry (Dr. Filley), University of Colorado Health Sciences Center, Denver, CO, and the Department of Psychiatry (Dr. Heaton), University of California at San Diego, San Diego, CA.

We studied 14 chronic toluene abusers with a comprehensive neuropsychological evaluation and cerebral magnetic resonance imaging (MRI). There were 10 men and 4 women, and the mean age was 29 years. Using a blinded global assessment of neuropsychological functioning, we found 3 patients to be normal, 3 in a borderline range, and 8 impaired. Independent analyses of white matter changes on MRI disclosed that the degree of white matter abnormality was strongly correlated (p < 0.01) with neuropsychological impairment. Dementia in toluene abuse appears to be related to severity of cerebral white matter involvement.

Address correspondence and reprint requests to Dr. Christopher M. Filley, UCHSC B-182.4200 E. 9th Avenue, Denver, CO 80262.

Supported by a grant from the National Institute on Drug Abuse (ROI DA-05311-01) awarded to Dr. Rosenberg. Dr. Rosenberg is a recipient of a Research Associate Award of the Veterans Administration.

Received May 9,1989. Accepted for publication in final form August 18,1989.






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