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Central lesions in chronic inflammatory demyelinating polyneuropathy

An MRI study

Department of Clinical Neurological Sciences (Drs. Feasby and Hahn, and W.J. Koopman), Victoria Hospital, and the Department of Radiology (Dr. Lee), University Hospital, University of Western Ontario, London, Ontario, Canada.

To determine the frequency of the possible association between chronic inflammatory demyelinating polyneuropathy (CIDP) and MS, we did magnetic resonance imaging (MRI) of the brain in 19 patients with CIDP. Only 1 patient had clinical signs suggestive of central involvement. Seven of the 19 scans showed 2 or more brain "lesions." In 1 case the cause was an infarct and in 5 cases the patients were over 55 years of age and the lesions were not typical of MS. One 38-year-old patient had 2 small subcortical lesions. Typical MS lesions on MRI are uncommon in CIDP.

Address correspondence and reprint requests to Dr. Thomas E. Feasby, Department of Clinical Neurological Sciences, Victoria Hospital, 375 South Street, London, ON N6A 4G5, Canada.

Received July 19,1989. Accepted for publication in final form August 31,1989.

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