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Age-induced cognitive disturbances in Parkinson's disease

Clinique de Neurologie et Neuropsychologie and INSERM U 289, Paris, France.

We investigated the influence of age on the occurrence of cognitive disturbances in Parkinson's disease (PD), by evaluating neuropsychological performances in early- and late-onset groupe of patients (<45 and >65 years, respectively), individually paired for all the variables of parkinsonism and compared with age-matched controls. Cognitive disorders were limited in the early-onset PD group compared with their age-matched controls. Conversely, we found global cognitive changes, including marked frontal lobe dysfunction, in the late-onset group. This specific cognitive impairment in older patients related to a significant interaction between the aging and disease processes. Late onset seemed to compound the subtle cognitive changes associated with the disease for which the early-onset group compensated. This compounding effect of aging may explain, at least partially, the high frequency of dementia in older PD patients.

Address correspondence and reprint requests to Dr. Bruno Dubois, Clinique de Neurologie et Neuropsychologie and INSERM U 289, Hôpital de la Salpêtrière, 47, Boulevard de l'Hôpital, 75651 Paris, Cedex 13, France.

Supported by a grant of the Caisse Nationale d'Assurance Maladie des Travailleurs Salariés (CNAMTS).

Received March 29, 1989. Accepted for publication in final form June 23, 1989.

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